Evidence map›Paper›PMID 35991901›Full record

ArticleFrontiers in pharmacology2022

Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens.

Liangliang He, Chunxia Xu, Ziying Wang, Shuyi Duan, Jinjin Xu, Chuan Li, Xinsheng Yao, Frank J Gonzalez, Zifei Qin, Zhihong Yao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Liangliang HeCollege of Pharmacy, Jinan University, Guangzhou, China.
Chunxia XuCollege of Pharmacy, Jinan University, Guangzhou, China.
Ziying WangSchool of Chemistry, University of Bristol, Bristol, United Kingdom.
Shuyi DuanDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jinjin XuCollege of Pharmacy, Jinan University, Guangzhou, China.
Chuan LiState key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xinsheng YaoCollege of Pharmacy, Jinan University, Guangzhou, China.
Frank J GonzalezCollege of Pharmacy, Jinan University, Guangzhou, China.
Zifei QinCollege of Pharmacy, Jinan University, Guangzhou, China.
Zhihong YaoCollege of Pharmacy, Jinan University, Guangzhou, China.
Jinan University · CNFirst Affiliated Hospital of Zhengzhou University · CNChinese Academy of Sciences · CNNational Institutes of Health · USUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xian-Ling-Gu-Bao (XLGB) capsule, a well-known traditional Chinese medicine prescription, is widely used for the treatment of osteoporosis. It could significantly increase the levels of estrogen in ovariectomized rats and mice. However, this working mechanism has not been well elucidated. Considering that UDP-glucuronosyltransferase (UGT) enzymes are the important enzymes that inactivate and regulate estrogen activity

Indexed as

estrogensglucuronidationinhibitory effectsUDP-glucuronosyltransferaseXian-Ling-Gu-Bao capsule

Identifiers

PMID35991901
PMCPMC9386001
OpenAlexW4289731229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.