Evidence map›Paper›PMID 35991686›Full record

ArticleNeurobiology of stress2022

Brain-wide mapping of c-Fos expression with fluorescence micro-optical sectioning tomography in a chronic sleep deprivation mouse model.

Guohong Cai, Yifan Lu, Jing Chen, Dingding Yang, Ruixuan Yan, Mudan Ren, Shuixiang He, Shengxi Wu, Yan Zhao

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Protective effect ofIranian journal of basic medical sciences · 2025
    Article
  16. Frontiers in cell and developmental biology · 2025
    Article
  17. Article
  18. An arginine-rich nuclear localization signal (ArgiNLS) strategy for streamlined image segmentation of single cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Guohong CaiDepartment of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710065, China.
Yifan LuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Jing ChenDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an, 710032, China.
Dingding YangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Ruixuan YanDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Mudan RenDepartment of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710065, China.
Shuixiang HeDepartment of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710065, China.
Shengxi WuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yan ZhaoDepartment of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710065, China.
Air Force Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNYanan University Affiliated Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic sleep deprivation (SD) is a common problem for humans and can lead to many deleterious effects, including depression, anxiety, stroke, permanent cognitive deficits, stress, and other physiological diseases. It is vital to acquire information about the relevant neural activities at the whole-brain level to systematically explore the mechanisms of brain dysfunction related to SD. Expression of the immediate-early gene (IEG)

Indexed as

c-FosFluorescence micro-optical sectioning tomographyImmediate-early genesSleep deprivation

Identifiers

PMID35991686
PMCPMC9389418
OpenAlexW4290988177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.