Evidence map›Paper›PMID 35991589›Full record

ArticleOpen forum infectious diseases2022

Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children-Maryland, New York, and Utah, August 2020-October 2021.

Kelsey M Sumner, Ruth A Karron, Melissa S Stockwell, Fatimah S Dawood, Joseph B Stanford, Alexandra Mellis, Emily Hacker, Priyam Thind, Maria Julia E Castro, John Paul Harris and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Kelsey M SumnerCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-4479-897X
Ruth A KarronCenter for Immunization Research, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Melissa S StockwellDivision of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Fatimah S DawoodCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Joseph B StanfordDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Alexandra MellisCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Emily HackerDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Priyam ThindDivision of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Maria Julia E CastroDivision of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
John Paul HarrisDivision of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Maria Deloria KnollInternational Vaccine Access Center, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Elizabeth SchappellCenter for Immunization Research, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Marissa K HetrichInternational Vaccine Access Center, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Jazmin DuqueAbt Associates, Cambridge, Massachusetts, USA.
Zuha JeddyAbt Associates, Cambridge, Massachusetts, USA.
Kim AltunkaynakAbt Associates, Cambridge, Massachusetts, USA.
Brandon PoeAbt Associates, Cambridge, Massachusetts, USA.
Jennifer MeeceMarshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Elisha StefanskiMarshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Suxiang TongCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Justin S LeeCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Ashton DixonCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Vic VeguillaCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Melissa A RolfesCenters for Disease Control and Prevention COVID-19 Response, Atlanta, Georgia, USA.
Christina A PorucznikDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
CDC Genomic Sequencing Laboratory, SEARCh and C-HEaRT Study Teams

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

Background: Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition of SARS-CoV-2. Methods: Households with children age <18 years were enrolled into prospective, longitudinal cohorts and followed from August 2020 to August 2021 in Utah, September 2020 to August 2021 in New York City, and November 2020 to October 2021 in Maryland. Participants self-collected nasal swabs weekly and with onset of acute illness. Swabs were tested for SARS-CoV-2 using reverse transcription polymerase chain reaction. We assessed factors associated with SARS-CoV-2 acquisition using a multilevel logistic regression adjusted for household size and clustering and SARS-CoV-2 transmission using a logistic regression adjusted for household size. Results: Among 2053 people (513 households) enrolled, 180 people (8.8%; in 76 households) tested positive for SARS-CoV-2. Compared with children age <12 years, the odds of acquiring infection were lower for adults age ≥18 years (adjusted odds ratio [aOR], 0.34; 95% CI, 0.14-0.87); however, this may reflect vaccination status, which protected against SARS-CoV-2 acquisition (aOR, 0.17; 95% CI, 0.03-0.91). The odds of onward transmission were similar between symptomatic and asymptomatic primary cases (aOR, 1.00; 95% CI, 0.35-2.93) and did not differ by age (12-17 years vs <12 years: aOR, 1.08; 95% CI, 0.20-5.62; ≥18 years vs <12 years: aOR, 1.70; 95% CI, 0.52-5.83). Conclusions: Adults had lower odds of acquiring SARS-CoV-2 compared with children, but this association might be influenced by coronavirus disease 2019 (COVID-19) vaccination, which was primarily available for adults and protective against infection. In contrast, all ages, regardless of symptoms and COVID-19 vaccination, had similar odds of transmitting SARS-CoV-2. Our findings underscore the importance of SARS-CoV-2 mitigation measures for persons of all ages.

Indexed as

COVID-19household transmissionSARS-CoV-2

Identifiers

PMID35991589
PMCPMC9384637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.