Evidence map›Paper›PMID 35991008›Full record

ArticleFrontiers in public health2022

Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study.

Jianhao Sun, Baohong Mao, Zhenzhen Wu, Xinjuan Jiao, Yanxia Wang, Yongli Lu, Xuejing Ma, Xiaohui Liu, Xiaoying Xu, Hongmei Cui and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
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  13. Co-exposure to iron, copper, zinc, selenium and titanium is associated with the prevention of gastric precancerous lesions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jianhao SunGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Baohong MaoGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Zhenzhen WuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Xinjuan JiaoSchool of Nursing, Gansu University of Chinese Medicine, Lanzhou, China.
Yanxia WangGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Yongli LuThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.
Xuejing MaThe First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.
Xiaohui LiuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Xiaoying XuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Hongmei CuiGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Xiaojuan LinGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Bin YiGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Jie QiuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Qing LiuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Gansu Provincial Maternal and Child Health Hospital · CNGansu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies have found that exposure to heavy metals increased the incidence of congenital heart defects (CHDs). However, there is a paucity of information about the connection between exposure to titanium and CHDs. This study sought to examine the relationship between prenatal titanium exposure and the risk of CHDs in offspring. Methods: We looked back on a birth cohort study that was carried out in our hospital between 2010 and 2012. The associations between titanium exposure and the risk of CHDs were analyzed by using logistic regression analysis to investigate titanium concentrations in maternal whole blood and fetal umbilical cord blood. Results: A total of 97 case groups and 194 control groups were included for a nested case-control study. The [P Conclusion: Titanium can cross the placental barrier and the occurrence of CHDs may be related to titanium exposure.

Indexed as

Heart Defects, CongenitalMetals, HeavyCase-Control StudiesChinaCohort StudiesFemaleHumansMaternal ExposurePlacentaPregnancyTitaniumMetals, HeavyTitaniumcongenital heart defectsmaternal bloodmetal exposurepregnancytitaniumumbilical cord blood

Identifiers

PMID35991008
PMCPMC9381958
OpenAlexW4289516564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.