ArticleFrontiers in cardiovascular medicine2022
Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Association Between Handgrip Strength and Mortality of Patients With Coronary Artery Disease: A Meta-Analysis.Clinical cardiology · 2024Pooled it
- Gingival bleeding as a predictor of handgrip strength-an observational study and a pilot randomized clinical trial.Clinical oral investigations · 2024Trial
- Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation.Lipids in health and disease · 2026Article
- Mediation of fasting blood glucose between relative muscle strength and hypertension: insights from two cohorts.Diabetology & metabolic syndrome · 2025Article
- Biological Sex and the Association Between Grip Strength and Cardiovascular Disease: a Scoping Review.Canadian geriatrics journal : CGJ · 2025Review
- Breaking the Cycle: Enhancing Cardiovascular Health in the Elderly Through Group Exercise.Life (Basel, Switzerland) · 2025Article
- Comment on 'Association Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank' by Lim et al.Journal of cachexia, sarcopenia and muscle · 2025Article
- Comment on 'Association Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank' by T. S. Lim et al.-Authors' Reply.Journal of cachexia, sarcopenia and muscle · 2025Article
- Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.GeroScience · 2023Article
- Causal relationship between spondylarthritis and stroke in a European population: a two sample Mendelian randomization study.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Background: Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated. Methods: We identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold ( Results: Genetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950-0.984; Conclusion: Our study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures.
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