Evidence map›Paper›PMID 35990958›Full record

ArticleFrontiers in cardiovascular medicine2022

Development of the Centrifugal Blood Pump for a Hybrid Continuous Flow Pediatric Total Artificial Heart: Model, Make, Measure.

Carson S Fox, Thomas Palazzolo, Matthew Hirschhorn, Randy M Stevens, Joseph Rossano, Steven W Day, Vakhtang Tchantchaleishvili, Amy L Throckmorton

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025
    Article
  3. Article
  4. Article
  5. Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Carson S FoxSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Thomas PalazzoloSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Matthew HirschhornSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Randy M StevensSt. Christopher's Hospital for Children, Philadelphia, PA, United States.
Joseph RossanoDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Steven W DayDepartment of Biomedical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, NY, United States.
Vakhtang TchantchaleishviliCardiac Surgery, Thomas Jefferson University, Philadelphia, PA, United States.
Amy L ThrockmortonSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Drexel University · USChildren's Hospital of Philadelphia · USRochester Institute of Technology · USSt. Christopher's Hospital for Children · USThomas Jefferson University · US

Funding

Multifunctional VAD Technology for High-Risk Pediatric PatientsR01HL153536 · NHLBI · DREXEL UNIVERSITY · PI THROCKMORTON, AMY · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL153536
6 · The paper itself

Abstract

Clinically-available blood pumps and total artificial hearts for pediatric patients continue to lag well behind those developed for adults. We are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). The hybrid TAH design integrates both an axial and centrifugal blood pump within a single, compact housing. The centrifugal pump rotates around the separate axial pump domain, and both impellers rotate around a common central axis. Here, we concentrate our development effort on the centrifugal blood pump by performing computational fluid dynamics (CFD) analysis of the blood flow through the pump. We also conducted transient CFD analyses (quasi-steady and transient rotational sliding interfaces) to assess the pump's dynamic performance conditions. Through modeling, we estimated the pressure generation, scalar stress levels, and fluid forces exerted on the magnetically levitated impellers. To further the development of the centrifugal pump, we also built magnetically-supported prototypes and tested these in an

Indexed as

pediatric mechanical circulatory supportpediatric total artificial heartpediatric ventricle assist devicepediatric ventricular supportrotary blood pumprotary blood pump modeling

Identifiers

PMID35990958
PMCPMC9386069
OpenAlexW4289730906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.