Evidence map›Paper›PMID 35990863›Full record

ArticleEuroasian journal of hepato-gastroenterology

Plasma Exchange in Patients of Acute on Chronic Liver Failure: An Observational Study in Bangladesh.

Abdullah Al Mukit, Mamun Al Mahtab, Md Abdur Rahim, Seikh Mohammad Noor-E-Alam, Dulal Chandra Das, Ahmed Lutful Moben, Faiz Ahmad Khondaker, Md Ashraful Alam, Rokshana Begum, Mohammad Ekramul Haque and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Euroasian journal of hepato-gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Abdullah Al MukitDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mamun Al MahtabDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-3728-3879
Md Abdur RahimDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Seikh Mohammad Noor-E-AlamDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Dulal Chandra DasDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Ahmed Lutful MobenDepartment of Hepatology, Kurmitola General Hospital, Dhaka, Bangladesh.
Faiz Ahmad KhondakerDepartment of Hepatology, Shaheed Suhrawardi Medical College, Dhaka, Bangladesh.
Md Ashraful AlamDepartment of Hepatology, Shaheed Tajuddin Ahmad Medical College, Gazipur, Bangladesh.
Rokshana BegumDepartment of Hepatology, Shaheed Suhrawardi Medical College, Dhaka, Bangladesh.
Mohammad Ekramul HaqueDepartment of Anaesthesia, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh.
Md Atikul IslamDepartment of Hepatology, Sheikh Russel Gastro liver Institute and Hospital, Dhaka, Bangladesh.
Ayub Al MamunDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Sheikh Mohammad Fazle AkbarDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
Bangladesh Medical University · BDNational Institute of Traumatology & Orthopaedic Rehabilitation · BDNational Institute of Neurosciences & Hospital · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Therapeutic plasma exchange (PLEX) removes toxins and different mediators from plasma in patients with acute-on-chronic liver failure (ACLF). Aim: To observe the safety and outcome of PLEX in ACLF patients in Bangladesh. Materials and methods: Twenty-eight patients with ACLF attending Bangabandhu Sheikh Mujib Medical University from September 2020 to May 2021 were enrolled in the study. The patients were given different treatment modalities and followed up for 3 months or up to death. The patients were divided into two groups, each containing 14 patients of ACLF. One group of 14 patients received standard medical therapy (SMT) for ACLF and the second group of 14 patients received SMT plus PLEX. Results: At 90 days, a total of 13 patients (46.43%) survived, of them 8 (57.1%) belonged to PLEX group and 5 (35.7%) were from SMT group. Serum bilirubin and ALT declined significantly after 7 and 30 days but not after 90 days in PLEX group in comparison to SMT group ( Conclusion: The study presented here has shown that PLEX is safe in Bangladeshi in ACLF patients, but its efficacy remains to be checked in large-scale randomized trial or in combination therapy with other procedures in ACLF patients. How to cite this article: Al Mukit A, Al Mahtab M, Rahim MA,

Indexed as

Acute on chronic liver failureParameters of liver diseasesPlasma exchangeSurvival

Identifiers

PMID35990863
PMCPMC9357523
OpenAlexW4285088262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.