Evidence map›Paper›PMID 35990727›Full record

ArticleFrontiers in behavioral neuroscience2022

Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes.

Molly H Kent, Joanna C Jacob, Gabby Bowen, Janhavi Bhalerao, Stephanie Desinor, Dylan Vavra, Danielle Leserve, Kelly R Ott, Benjamin Angeles, Michael Martis and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Molly H KentDepartment of Biology, Virginia Military Institute, Lexington, VA, United States.
Joanna C JacobDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Gabby BowenDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Janhavi BhaleraoDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Stephanie DesinorDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Dylan VavraDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Danielle LeserveDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Kelly R OttDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Benjamin AngelesDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Michael MartisDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Katherine SciandraDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Katherine GillenwaterDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Clark GloryDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Eli MeiselDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Allison ChoeDepartment of Psychology, University of Richmond, Richmond, VA, United States.
Rene Olivares-NavarreteDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Jennifer L PuetzerDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Kelly LambertDepartment of Psychology, University of Richmond, Richmond, VA, United States.
University of Richmond · USVirginia Commonwealth University · USVirginia Military Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When a maternal rat nurtures her pups, she relies on adequate resources to provide optimal care for her offspring. Accordingly, limited environmental resources may result in atypical maternal care, disrupting various developmental outcomes. In the current study, maternal Long-Evans rats were randomly assigned to either a standard resource (SR) group, provided with four cups of bedding and two paper towels for nesting material or a limited resource (LR) group, provided with a quarter of the bedding and nesting material provided for the SR group. Offspring were monitored at various developmental phases throughout the study. After weaning, pups were housed in same-sex dyads in environments with SRs for continued observations. Subsequent behavioral tests revealed a sex × resource interaction in play behavior on PND 28; specifically, LR reduced play attacks in males while LR increased play attacks in females. A sex × resource interaction was also observed in anxiety-related responses in the open field task with an increase in thigmotaxis in LR females and, in the social interaction task, females exhibited more external rears oriented away from the social target. Focusing on morphological variables, tail length measurements of LR males and females were shorter on PND 9, 16, and 21; however, differences in tail length were no longer present at PND 35. Following the behavioral assessments, animals were perfused at 56 days of age and subsequent immunohistochemical assays indicated increased glucocorticoid receptors in the lateral habenula of LR offspring and higher c-Fos immunoreactivity in the basolateral amygdala of SR offspring. Further, when tail vertebrae and tail tendons were assessed via micro-CT and hydroxyproline assays, results indicated increased trabecular separation, decreased bone volume fraction, and decreased connectivity density in bones, along with reduced collagen concentration in tendons in the LR animals. In sum, although the restricted resources only persisted for a brief duration, the effects appear to be far-reaching and pervasive in this early life stress animal model.

Indexed as

boneearly life stressglucocorticoidslateral habenulamaternal resource deprivationpostnatal developmentrat

Identifiers

PMID35990727
PMCPMC9389412
OpenAlexW4289878613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.