Evidence map›Paper›PMID 35990644›Full record

ArticleFrontiers in immunology2022

Regulation of the Signal-Dependent E Protein HEBAlt Through a YYY Motif Is Required for Progression Through T Cell Development.

Kogulan Yoganathan, Anqi Yan, Juliana Rocha, Ashton Trotman-Grant, Mahmood Mohtashami, Lisa Wells, Juan Carlos Zúñiga-Pflücker, Michele K Anderson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Haematologica · 2026
    Article
  2. Article
  3. HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kogulan YoganathanBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Anqi YanBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Juliana RochaBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Ashton Trotman-GrantBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Mahmood MohtashamiBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Lisa WellsBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Juan Carlos Zúñiga-PflückerBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Michele K AndersonBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Sunnybrook Hospital · CASunnybrook Research Institute

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI DAVID L. WIEST · 2014 to 2026
$26.3M
NIAID NIH HHS P01 AI102853
6 · The paper itself

Abstract

The E protein transcription factors E2A and HEB are critical for many developmental processes, including T cell development. We have shown that the

Indexed as

Basic Helix-Loop-Helix ProteinsCell DifferentiationT-LymphocytesAnimalsKineticsMiceProteomicsTranscription FactorsBasic Helix-Loop-Helix ProteinsTcf12 protein, mouseTranscription Factorsgene expressionHEBsignal transductionT cell developmentTCF12

Identifiers

PMID35990644
PMCPMC9385190
OpenAlexW4289517410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.