ArticleEClinicalMedicine2022
Lethal diquat poisoning manifests as acute central nervous system injury and circulatory failure: A retrospective cohort study of 50 cases.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Charge reversible-natural light responsive nanoparticles enable targeted herbicide delivery and reduction of mammalian toxicity.Journal of advanced research · 2026Article
- Pre-treatment with baicalein alleviates the diquat-induced microglial pyroptosis through gut microbiota-derived indole-3-propionic acid and DDX3X/G3BP1 pathway.Cell biology and toxicology · 2026Article
- A novel low-metabolism strategy combined with multimodal detoxification for successful management of high-dose diquat-paraquat mixed poisoning: A comprehensive therapeutic analysis.The Journal of international medical research · 2026Article
- Development and validation of a bedside prognostic model for in-hospital mortality in acute diquat poisoning.BMC emergency medicine · 2026Article
- Independent risk factors for clinically significant acute poisoning in children presenting to the emergency department: a 4-year cohort study of 2,345 cases.Frontiers in pediatrics · 2026Article
- Combined predictive value of dose, MODS, and NLR for lethal risk of diquat poisoning: a retrospective cohort study.Frontiers in toxicology · 2026Article
- Acute diquat poisoning in children: a single-center retrospective observational study.Frontiers in pediatrics · 2026Article
- Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning.iScience · 2025Article
- Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome.Antioxidants (Basel, Switzerland) · 2025Review
- The association between enema and nervous system injury in Diquat poisoning.Scientific reports · 2025Article
- Risk factors for death in patients with acute diquat poisoning.World journal of emergency medicine · 2025Article
- Case Report: A case of subarachnoid hemorrhage secondary to elbow intravenous injection of diquat poisoning in young male.Frontiers in public health · 2025Article
- Case report: A case of acute renal failure, rhabdomyolysis, and toxic encephalopathy associated with diquat poisoning in a pregnant woman.Frontiers in medicine · 2025Article
- Construction and validation of a nomogram model to predict mortality risk in patients with acute diquat poisoning.American journal of translational research · 2025Article
- Early Immune-Inflammatory Profiling and Prognostic Biomarkers in Patients with Acute Diquat Poisoning: A Multicenter Study with Exploratory Bioinformatics Analysis.Journal of inflammation research · 2025Article
- Optimization of concentration-directed blood purification therapy in the management of diquat poisoning.Frontiers in medicine · 2025Article
- Clinical characteristics of survivors versus non-survivors after acute diquat poisoning: a comparative study-comment.Internal and emergency medicine · 2024Article
- Interpretable machine learning for the prediction of death risk in patients with acute diquat poisoning.Scientific reports · 2024Article
- Vascular endothelium, a promising target for effectively treating fulminant diquat intoxication?World journal of clinical cases · 2024Article
- Construction of a mortality risk prediction model for patients with acute diquat poisoning based on clinically accessible data.Journal of occupational medicine and toxicology (London, England) · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The mortality rate of patients with diquat (DQ) poisoning is extremely high due to insufficient understanding of DQ-induced injury. This study aimed to summarize the characteristics of DQ poisoning as well as analyse the correlation between plasma DQ concentration and patient outcomes, thus providing a new strategy for diagnosis and treatment. Methods: This single-centre retrospective cohort study was conducted at the Emergency Department of the First Affiliated Hospital, Zhejiang University School of Medicine, China, between Oct 9, 2019 and March 10, 2022. 50 patients, whose plasma or urine samples tested positive for diquat and negative for paraquat by high performance liquid chromatography-tandem mass spectrometry, were included in the study. Findings: The mortality rate of acute DQ poisoning was 25 (50%) of 50. Compared with the survival group, the death group presented significantly higher initial plasma DQ concentration (Cp Interpretation: Lethal DQ poisoning is primarily associated with serious brain and vascular injury, as well as a high rate of mortality. Further research into the mechanisms of refractory circulatory failure and central nerve system damage could help reduce mortality. Funding: There are no funding sources to declare.
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