ArticleACS omega2022
Electrospun Nanofibrous Scaffolds of Polycaprolactone/Gelatin Reinforced with Layered Double Hydroxide Nanoclay for Nerve Tissue Engineering Applications.
Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Cytotoxicity evaluation, porosity and physicochemical study of bioactive glass nanocomposites for tissue engineering.Toxicology reports · 2026Article
- Fabrication and Optimization of a Polycaprolactone-Based Ductular Blood-Brain Barrier Model Using an Electrospinning Technique.ACS omega · 2026Article
- Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical Applications.Biopolymers · 2026Article
- Cotton-Type Nanofiber Guided Pathway Engineering Enables Rapid Tissue Integration and Accelerated Bone Regeneration in Mineral Powder-Based Bone Grafts.Journal of functional biomaterials · 2026Article
- FibreCastML: an open web platform for predicting electrospun nanofibre diameter distributions for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Article
- Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF-TrFE Nanofiber Scaffolds.Advanced materials technologies · 2025Article
- Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives.Journal of nanobiotechnology · 2025Review
- How to Deal with Pulpitis: An Overview of New Approaches.Dentistry journal · 2025Review
- Development of Nanofiber Mats Impregnated WithInternational journal of biomaterials · 2025Article
- Fibrin-Polycaprolactone Scaffolds for the Differentiation of Human Neural Progenitor Cells into Dopaminergic Neurons.ACS omega · 2024Article
- Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields.Pharmaceutics · 2023Review
- Nanofibrous Scaffolds for Diabetic Wound Healing.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve tissue engineering (NTE) is an effective approach for repairing damaged nerve tissue. In this regard, nanoparticle-incorporated electrospun scaffolds have aroused a great deal of interest in NTE applications. In this study, layered double hydroxide (LDH)-incorporated polycaprolactone (PCL)/gelatin (Gel) nanofibrous scaffolds were fabricated by an electrospinning technique. The physicochemical, mechanical, and biological properties of the scaffolds were examined. Also, the phase identification, morphology, and elemental composition were studied using X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, respectively. The results revealed that the inclusion of LDH nanoparticles into the PCL/Gel scaffold has improved its mechanical strength and elongation at the break, while the degradation rate was enhanced in comparison with the pure PCL/Gel mat. The LDH-enriched electrospun PCL/Gel scaffolds exhibited a considerable impact on cell attachment and proliferation. The gene expression results showed that the neuron-specific (γγ) enolase (NSE) gene expression was significantly decreased in the scaffolds containing 1 and 10 wt % LDH compared to the scaffold without LDH, whereas in the scaffold with 0.1 wt % LDH, a slight increase in expression was observed. It can be deduced that electrospun PCL/Gel scaffolds containing LDH with optimum concentration can be a promising candidate for nerve tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.