Evidence map›Paper›PMID 35990476›Full record

ArticleACS omega2022

Synthesis and Evaluation of

John F Ciprich, Alexander J E Buckhalt, Lane L Carroll, David Chen, Steven A DeFiglia, Riley S McConnell, Dhruvi J Parmar, Olivia L Pistor, Aliyah B Rao, M Lillian Rubin and 3 more

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Quinoline Compounds Targeting theACS infectious diseases · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John F CiprichDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Alexander J E BuckhaltDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Lane L CarrollDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
David ChenDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Steven A DeFigliaDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Riley S McConnellDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.ORCID https://orcid.org/0000-0002-8611-0280
Dhruvi J ParmarDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Olivia L PistorDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Aliyah B RaoDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
M Lillian RubinDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Grace E VolkDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
P Ryan SteedDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.
Amanda L WolfeDepartment of Chemistry and Biochemistry, University of North Carolina Asheville, One University Heights, Asheville, North Carolina 28804, United States.ORCID https://orcid.org/0000-0003-1867-6861

Funding

Targeted development and selective delivery of small molecule antibiotics for the treatment of multidrug resistant Pseudomonas aeruginosa infectionsR15AI163474 · NIAID · UNIVERSITY OF NORTH CAROLINA ASHEVILLE · PI Amanda Lynn Wolfe · 2021 to 2026
$889k
NIAID NIH HHS R15 AI163474
6 · The paper itself

Abstract

New antibiotics with unique biological targets are desperately needed to combat the growing number of resistant bacterial pathogens. ATP synthase, a critical protein found in all life, has recently become a target of interest for antibiotic development due to the success of the anti-tuberculosis drug bedaquiline, and while many groups have worked on developing drugs to target bacterial ATP synthase, few have been successful at inhibiting

Identifiers

PMID35990476
PMCPMC9386795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.