Evidence map›Paper›PMID 35990424›Full record

ArticleACS omega2022

Development of an Automatable Affinity Purification Process for DNA-Encoded Chemistry.

Katharina Götte, Robin Dinter, Leon Justen, Norbert Kockmann, Andreas Brunschweiger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katharina GötteDepartment of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.
Robin DinterDepartment of Chemical and Biochemical Engineering, Laboratory of Equipment Design, TU Dortmund University, Emil-Figge-Str. 68, 44227 Dortmund, Germany.ORCID https://orcid.org/0000-0002-2765-2362
Leon JustenDepartment of Chemical and Biochemical Engineering, Laboratory of Equipment Design, TU Dortmund University, Emil-Figge-Str. 68, 44227 Dortmund, Germany.
Norbert KockmannDepartment of Chemical and Biochemical Engineering, Laboratory of Equipment Design, TU Dortmund University, Emil-Figge-Str. 68, 44227 Dortmund, Germany.ORCID https://orcid.org/0000-0002-8852-3812
Andreas BrunschweigerDepartment of Chemistry and Chemical Biology, Medicinal Chemistry, TU Dortmund University, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.ORCID https://orcid.org/0000-0002-4401-1495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-encoded library technologies require high-throughput, compatible, and well automatable platforms for chemistry development, building block rehearsal, and library synthesis. An affinity-based process using Watson-Crick interactions was developed that enables purification of DNA-tagged compounds from complex reaction mixtures. The purification relies on a single-stranded DNA-oligonucleotide, called

Identifiers

PMID35990424
PMCPMC9386796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.