Evidence map›Paper›PMID 35990384›Full record

ArticleClinical case reports2022

Primary hypothyroidism resolves after switching from L-thyroxine solid tablets to liquid oral substitution. A rare case without evidence of an underlying gastrointestinal malabsorption syndrome.

Sophie Stupperich, Jessica Kotliarevskaia, Reinhold Nies, Maria Paparoupa, Andreas Wittig, Frank Schuppert

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophie StupperichDepartment of Gastroenterology, Endocrinology Diabetology and General Medicine Kassel Germany.ORCID https://orcid.org/0000-0001-7811-6546
Jessica KotliarevskaiaDepartment of Gastroenterology, Endocrinology Diabetology and General Medicine Kassel Germany.
Reinhold NiesGeneral Practitioner's Private Practice Hofgeismar Germany.
Maria PaparoupaDepartment of Intensive Care Medicine University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID https://orcid.org/0000-0003-1713-6759
Andreas WittigDepartment of Gastroenterology, Endocrinology Diabetology and General Medicine Kassel Germany.
Frank SchuppertDepartment of Gastroenterology, Endocrinology Diabetology and General Medicine Kassel Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A case of refractory primary hypothyroidism is presented. Despite laboratory-guided hormonal substitution, the patient remained hypothyroid. Multiple diagnostic tests ruled out all known causes of levothyroxine malabsorption. Interestingly, clinical and laboratory responding was promptly achieved, after switching the application format from solid tablets to liquid formula.

Indexed as

levothyroxineL‐thyroxinemalabsorptionthyroid hormones

Identifiers

PMID35990384
PMCPMC9376134

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.