ArticleFrontiers in neurology2022
Effectiveness and safety of EVT in patients with acute LVO and low NIHSS.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Integrated predictors of outcome in vertebrobasilar artery occlusion treated With endovascular therapy.Frontiers in surgery · 2026Review
- Preoperative Neurological Changes on Outcomes in Large-Vessel Occlusion Due to Intracranial Atherosclerotic Disease.Neurosurgery practice · 2025Article
- Advancements and emerging trends in photodynamic therapy: innovations in cancer treatment and beyond.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Review
- Effectiveness and Safety of Endovascular Treatment in Large Vessel Occlusion Stroke with an NIHSS Score of ≤5 Exhibiting Predominant Cortical Signs.Biomedicines · 2025Article
- Effectiveness and Safety of Mechanical Thrombectomy in Mild Stroke due to Large-Vessel Occlusion: Insights from the ASSIST Registry.AJNR. American journal of neuroradiology · 2025Article
- Tenecteplase for Minor Stroke: Does Sex Matter?Journal of the American Heart Association · 2025Article
- Low NIHSS score in large vessel occlusion stroke: optimal treatment and clinical controversies.Frontiers in neurology · 2025Review
- Prevalence and outcomes of mild stroke patients undergoing reperfusion therapy: A meta-analysis and SAFE recommendations for optimal management.Journal of central nervous system disease · 2025Article
- Is Thrombectomy Effective for Large Vessel Occlusion Stroke Patients with Mild Symptoms? Meta-Analysis and Trial Sequential Analysis.Life (Basel, Switzerland) · 2024Article
- Brain Frailty and Outcomes of Acute Minor Ischemic Stroke With Large-Vessel Occlusion.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Outcome in acute ischemic stroke patients with large-vessel occlusion and initial mild deficits.Frontiers in stroke · 2024Article
- Leptomeningeal Collaterals and Infarct Progression in Patients With Acute Large-Vessel Occlusion and Low NIHSS.Stroke (Hoboken, N.J.) · 2023Article
- Combined Therapeutics: Future Opportunities for Co-therapy with Thrombectomy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Biomarker of early neurological deterioration in minor stroke and proximal large vessel occlusion: A pilot study.Frontiers in neurology · 2022Article
- Endovascular treatment of low NIHSS score(<6) combined with large vessel occlusion: a meta-analysis.Frontiers in neurologyReview
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47 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: There is much uncertainty in endovascular treatment (EVT) decisions in patients with acute large vessel occlusion (LVO) and mild neurological deficits. Methods: From a prospective, nationwide stroke registry, all patients with LVO and baseline NIHSS <6 presenting within 24 h from the time last known well (LKW) were included. Early neurological deterioration (END) developed before EVT was prospectively collected as an increasing total NIHSS score ≥2 or any worsening of the NIHSS consciousness or motor subscores during hospitalization not related to EVT. Significant hemorrhage was defined as PH2 hemorrhagic transformation or hemorrhage at a remote site. The modified Rankin Scale (mRS) was prospectively collected at 3 months. Results: Among 1,083 patients, 149 (14%) patients received EVT after a median of 5.9 [3.6-12.3] h after LKW. In propensity score-matched analyses, EVT was not associated with mRS 0-1 (matched OR 0.99 [0.63-1.54]) but increased the risk of a significant hemorrhage (matched OR, 4.51 [1.59-12.80]). Extraneous END occurred in 207 (19%) patients after a median of 24.5 h [IQR, 13.5-41.9 h] after LKW (incidence rate, 1.41 [95% CI, 1.23-1.62] per 100 person-hours). END unrelated to EVT showed a tendency to modify the effectiveness of EVT (P-for-interaction, 0.08), which decreased the odds of having mRS 0-1 in mild LVO patients without END (adjusted OR, 0.63 [0.40-0.99]). Conclusions: The use of EVT in patients with acute LVO and low NIHSS scores may require the assessment of individual risks of early deterioration, hemorrhagic complications and expected benefit.
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