ArticleFrontiers in neurology2022
Correlation between neutrophil/lymphocyte ratio and cognitive impairment in cerebral small vessel disease patients: A retrospective study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Risk prediction models for cognitive impairment in patients with cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Association between neutrophil-to-lymphocyte ratio and cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Circulating immune cells in cerebral small vessel disease: a systematic review.Biogerontology · 2025Pooled it
- Association between the neutrophil-to-lymphocyte ratio and cognitive impairment: a meta-analysis of observational studies.Frontiers in endocrinology · 2023Pooled it
- The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values.Integrative cancer therapiesTrial
- Biomarker advancements in cerebral small vessel disease: An overview.Neural regeneration research · 2026Article
- The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Associations of Neutrophil-to-Lymphocyte Ratio with Cerebral Small Vessel Disease and Functional Outcome in Acute Ischaemic Stroke Patients.Life (Basel, Switzerland) · 2026Article
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio.Frontiers in psychiatry · 2026Article
- The correlation between neutrophil/lymphocyte ratio and the MRI burden and cognitive function in patients with cerebral small vessel disease.Frontiers in neurology · 2025Article
- Correlation between peripheral blood inflammatory markers and delayed cerebral ischemia after intracerebral hemorrhage.American journal of translational research · 2024Article
- RETRACTED: Neutrophil-Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study.Brain sciences · 2023Article
- Investigating the Prognostic Role of Peripheral Inflammatory Markers in Mild Cognitive Impairment.Journal of clinical medicine · 2023Article
- Higher Neutrophil to Lymphocyte Ratio at Admission is Association with Post-PCI Depressive Symptoms in Patients with ACS.Neuropsychiatric disease and treatment · 2022Article
- Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: The blood neutrophil/lymphocyte ratio (NLR) is an objective and convenient parameter of systemic inflammation. Elevated NLR is associated with an increased risk of mild cognitive impairment (CI) in the elderly. However, few data are available on the impact of the NLR on CI in patients with cerebral small vessel disease (CSVD). Methods: A total of 66 CSVD subjects with CI and 81 CSVD subjects without CI were evaluated in this study. Clinical, laboratory, radiological, and cognitive parameters were collected. The NLR was obtained with the absolute neutrophil count being divided by the absolute lymphocyte count in fasting blood samples. Logistic regression analysis was performed to evaluate the factors associated with CI. Receiver operating characteristic curves were illustrated to predict factors associated with CI in patients with CSVD. Results: The NLR of the CI group was significantly higher than that of subjects without CI (2.59 vs. 2.21, Conclusions: Correlations were found between NLR and CI. Patients with CSVD who have higher NLR might have an increased risk of CI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.