Evidence map›Paper›PMID 35989908›Full record

ArticleFrontiers in neurology2022

Adjuvant medical therapy in cervical dystonia after deep brain stimulation: A retrospective analysis.

Alfonso E Martinez-Nunez, Christos Sidiropoulos, Julia Wall, Jason Schwalb, Ellen Air, Peter LeWitt, Bisena Bulica, Patricia Kaminski, Neepa Patel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alfonso E Martinez-NunezDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Christos SidiropoulosDepartment of Neurology and Ophthalmology, Michigan State University, East Lansing, MI, United States.
Julia WallDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Jason SchwalbDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States.
Ellen AirDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States.
Peter LeWittDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Bisena BulicaDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Patricia KaminskiDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Neepa PatelParkinson's Disease and Movement Disorders Program, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States.
Henry Ford Hospital · USMichigan State University · USRush University Medical Center · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is limited information on optimization of symptomatic management of cervical dystonia (CD) after implantation of pallidal deep brain stimulation (DBS). Objectives: To describe the long-term, "real-world" management of CD patients after DBS implantation and the role of reintroduction of pharmacologic and botulinum toxin (BoNT) therapy. Methods: A retrospective analysis of patients with focal cervical or segmental craniocervical dystonia implanted with DBS was conducted. Results: Nine patients were identified with a mean follow-up of 41.7 ± 15.7 months. All patients continued adjuvant oral medication(s) to optimize symptom control post-operatively. Three stopped BoNT and four reduced BoNT dose by an average of 22%. All patients remained on at least one medication used to treat dystonia post-operatively. Conclusion: Optimal symptom control was achieved with DBS combined with either BoNT and/or medication. We suggest utilization of adjuvant therapies such as BoNT and/or medications if DBS monotherapy does not achieve optimal symptom control.

Indexed as

botulinum toxincervical dystoniadeep brain stimulationlong-term follow upmedical therapy

Identifiers

PMID35989908
PMCPMC9389307
OpenAlexW4289868579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.