Evidence map›Paper›PMID 35989614›Full record

ArticleWomen's health (London, England)

Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project.

Virginia A Aparicio, Laura Baena-García, Marta Flor-Alemany, Luis J Martínez-González, Alfonso Varela-López, Cristina Sánchez, José L Quiles

Open access · goldAbstract read
In one paragraph

Article in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Virginia A AparicioDepartment of Physiology, Institute of Nutrition and Food Technology and Biomedical Research Centre, University of Granada, Granada, Spain.
Laura Baena-GarcíaSport and Health University Research Centre, University of Granada, Granada, Spain.ORCID 0000-0002-4895-567X
Marta Flor-AlemanyDepartment of Physiology, Institute of Nutrition and Food Technology and Biomedical Research Centre, University of Granada, Granada, Spain.
Luis J Martínez-GonzálezGENYO: Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.ORCID 0000-0003-2202-0662
Alfonso Varela-LópezDepartment of Physiology, Institute of Nutrition and Food Technology and Biomedical Research Centre, University of Granada, Granada, Spain.
Cristina SánchezDepartment of Physiology, Institute of Nutrition and Food Technology and Biomedical Research Centre, University of Granada, Granada, Spain.
José L QuilesDepartment of Physiology, Institute of Nutrition and Food Technology and Biomedical Research Centre, University of Granada, Granada, Spain.
Universidad de Granada · ESPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex.

methodsOne hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018.

resultsMothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (

conclusionOur findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males' foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.

Indexed as

Cardiovascular DiseasesPlacentaBiomarkersCross-Sectional StudiesDNAFemaleFibroblast Growth Factor 2HumansInfant, NewbornMalePregnancySex FactorsUric AcidVascular Endothelial Growth Factor ABiomarkersDNAFibroblast Growth Factor 2Uric AcidVascular Endothelial Growth Factor Afibroblast Growth Factorlipidsnewbornpregnancytelomeretriglycerides

Identifiers

PMID35989614
PMCPMC9393354
OpenAlexW4292543217

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.