Evidence map›Paper›PMID 35989605›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022

The effect of sequencing and assembly on the inference of horizontal gene transfer on chromosomal and plasmid phylogenies.

Jana S Huisman, Timothy G Vaughan, Adrian Egli, Sarah Tschudin-Sutter, Tanja Stadler, Sebastian Bonhoeffer

Open access · hybridAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. The effect of sequencing and assembly on the inference of horizontal gene transfer on chromosomal and plasmid phylogenies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  8. Genomic population structures of microbial pathogens.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 5 countries.

Jana S HuismanDepartment of Environmental Systems Science, ETH Zurich, 8092 Zurich, Switzerland.ORCID 0000-0002-1782-8109
Timothy G VaughanDepartment of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
Adrian EgliDivision of Clinical Microbiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
Sarah Tschudin-SutterDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
Tanja StadlerDepartment of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.ORCID 0000-0001-6431-535X
Sebastian BonhoefferDepartment of Environmental Systems Science, ETH Zurich, 8092 Zurich, Switzerland.
SIB Swiss Institute of Bioinformatics · CHUniversity of Basel · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of antibiotic resistance genes on plasmids is a threat to human and animal health. Phylogenies of bacteria and their plasmids contain clues regarding the frequency of plasmid transfer events, as well as the co-evolution of plasmids and their hosts. However, whole genome sequencing data from diverse ecological or clinical bacterial samples are rarely used to study plasmid phylogenies and resistance gene transfer. This is partially due to the difficulty of extracting plasmids from short-read sequencing data. Here, we use both short- and long-read sequencing data of 24 clinical extended-spectrum [Formula: see text]-lactamase (ESBL)-producing

Indexed as

Gene Transfer, HorizontalGenome, BacterialAnimalsAnti-Bacterial AgentsEscherichia coliHumansPhylogenyPlasmidsSequence Analysis, DNAAnti-Bacterial Agentsantibiotic resistanceassemblylong-read sequencingphylogeneticsplasmidwhole-genome sequencing

Identifiers

PMID35989605
PMCPMC9393563
OpenAlexW4292574940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.