Evidence map›Paper›PMID 35989603›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022

Scalable Bayesian phylogenetics.

Alexander A Fisher, Gabriel W Hassler, Xiang Ji, Guy Baele, Marc A Suchard, Philippe Lemey

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Global, regional, and national burden of Early-onset Parkinson's disease: A comprehensive analysis and forecast, 1990-2021.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Genomic population structures of microbial pathogens.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander A FisherDepartment of Statistical Science, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-8381-6587
Gabriel W HasslerDepartment of Computational Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA.
Xiang JiDepartment of Mathematics, School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.
Guy BaeleDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Marc A SuchardDepartment of Computational Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA.
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Bryan Briney · 2018 to 2026
$32.0M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
Spread and Evolution of West Nile virus in the United StatesR56AI149004 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD · 2020 to 2020
$912k
Scalable Inference in Statistical Models of Viral Evolution and Human HealthF31AI154824 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HASSLER, GABRIEL WILLIAM · 2021 to 2022
$64k
NHGRI NIH HHS T32 HG002536NIAID NIH HHS F31 AI154824NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611NIAID NIH HHS R56 AI149004NIAID NIH HHS U19 AI135995Wellcome TrustWellcome Trust 206298/Z/17/Z
6 · The paper itself

Abstract

Recent advances in Bayesian phylogenetics offer substantial computational savings to accommodate increased genomic sampling that challenges traditional inference methods. In this review, we begin with a brief summary of the Bayesian phylogenetic framework, and then conceptualize a variety of methods to improve posterior approximations via Markov chain Monte Carlo (MCMC) sampling. Specifically, we discuss methods to improve the speed of likelihood calculations, reduce MCMC burn-in, and generate better MCMC proposals. We apply several of these techniques to study the evolution of HIV virulence along a 1536-tip phylogeny and estimate the internal node heights of a 1000-tip SARS-CoV-2 phylogenetic tree in order to illustrate the speed-up of such analyses using current state-of-the-art approaches. We conclude our review with a discussion of promising alternatives to MCMC that approximate the phylogenetic posterior. This article is part of a discussion meeting issue 'Genomic population structures of microbial pathogens'.

Indexed as

COVID-19SoftwareAlgorithmsBayes TheoremHumansMarkov ChainsMonte Carlo MethodPhylogenySARS-CoV-2adapative MCMCBayesian phylogeneticsBEASTHamiltonian Monte Carloonline inferencescalable inference

Identifiers

PMID35989603
PMCPMC9393558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.