Evidence map›Paper›PMID 35989573›Full record

ArticleThe Journal of neuropsychiatry and clinical neurosciences2023

Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents.

Jeffrey E Max, Imogen Drake, Florin Vaida, John R Hesselink, Linda Ewing-Cobbs, Russell J Schachar, Sandra B Chapman, Erin D Bigler, Elisabeth A Wilde, Ann E Saunders and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuropsychiatry and clinical neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jeffrey E MaxDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Imogen DrakeDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Florin VaidaDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
John R HesselinkDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Linda Ewing-CobbsDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Russell J SchacharDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Sandra B ChapmanDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Erin D BiglerDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Elisabeth A WildeDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Ann E SaundersDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Tony T YangDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Olga TymofiyevaDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Harvey S LevinDepartment of Psychiatry (Max), Division of Biostatistics & Bioinformatics, Herbert Wertheim School of Public Health (Vaida), and Department of Radiology (Hesselink), University of California, San Diego; Rady Children's Hospital, San Diego (Max); Taconic Hills High School, Craryville, New York (Drake); University of Texas Health Science Center at Houston (Ewing-Cobbs, Saunders); The Hospital for Sick Children, University of Toronto(Schachar); Center for BrainHealth, The University of Texas at Dallas (Chapman); Department of Psychology, Brigham Young University, Provo, Utah (Bigler); Department of Neurology, University of Utah, Salt Lake City (Bigler, Wilde); Department of Psychiatry and Behavioral Sciences (Yang) and Department of Radiology and Biomedical Imaging (Tymofiyeva), University of California, San Francisco; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston (Wilde, Levin).
Rady Children's Hospital-San Diego · US

Funding

Magnetoencephalography and Neurobehavioral Outcome of Pediatric Traumatic Brain InjuryR01HD088438 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAX, JEFFREY EDWIN · 2017 to 2021
$3.1M
SECONDARY ATTENTION DEFICIT HYPERACTIVITY DISORDERK08MH001800 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI MAX, JEFFREY E · 2000 to 2004
$839k
Neural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome studyR61AT009864 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TYMOFIYEVA, OLGA, YANG, TONY TUNG-I · 2019 to 2020
$822k
NCCIH NIH HHS R61 AT009864NICHD NIH HHS R01 HD088438NIMH NIH HHS K08 MH001800
6 · The paper itself

Abstract

objectiveTo investigate the factors predictive of novel psychiatric disorders in the interval 0-6 months following traumatic brain injury (TBI).

methodsChildren ages 5-14 years consecutively hospitalized for mild to severe TBI at five hospitals were recruited. Participants were evaluated at baseline (soon after injury) for pre-injury characteristics including psychiatric disorders, socioeconomic status (SES), psychosocial adversity, family function, family psychiatric history, and adaptive function. In addition to the psychosocial variables, injury severity and lesion location detected with acquisition of a research MRI were measured to develop a biopsychosocial predictive model for development of novel psychiatric disorders. Psychiatric outcome, including occurrence of a novel psychiatric disorder, was assessed 6 months after the injury.

resultsThe recruited sample numbered 177 children, and 141 children (80%) returned for the six-month assessment. Of the 141 children, 58 (41%) developed a novel psychiatric disorder. In univariable analyses, novel psychiatric disorder was significantly associated with lower SES, higher psychosocial adversity, and lesions in frontal lobe locations, such as frontal white matter, superior frontal gyrus, inferior frontal gyrus, and orbital gyrus. Multivariable analyses found that novel psychiatric disorder was independently and significantly associated with frontal-lobe white matter, superior frontal gyrus, and orbital gyrus lesions.

conclusionThe results demonstrate that occurrence of novel psychiatric disorders following pediatric TBI requiring hospitalization is common and has identifiable psychosocial and specific biological predictors. However, only the lesion predictors were independently related to this adverse psychiatric outcome.

Indexed as

Brain InjuriesBrain Injuries, TraumaticMental DisordersAdolescentChildChild, PreschoolHumansMagnetic Resonance ImagingPrefrontal CortexChildhood Neuropsychiatric DisordersTraumatic Brain Injury

Identifiers

PMID35989573
PMCPMC10317586
OpenAlexW4292572680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.