Evidence map›Paper›PMID 35989467›Full record

ArticleClinical transplantation2022

Pre-transplant cognitive screening is a poor predictor of post-transplant cognitive status.

Aditi Gupta, Robert N Montgomery, Kate Young, Rishav Mukherjee, Shweta Chakraborty, Tashra S Thomas, Diane M Cibrik, David Drew, Mark Sarnak

Open access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Changes in Cognitive Function After Kidney Transplantation: A Longitudinal Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aditi GuptaCenter for Transplantation, University of Kansas Medical Center, Kansas City, USA.ORCID 0000-0002-6286-802X
Robert N MontgomeryDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, USA.
Kate YoungDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, USA.
Rishav MukherjeeDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, USA.
Shweta ChakrabortyCenter for Transplantation, University of Kansas Medical Center, Kansas City, USA.
Tashra S ThomasCenter for Transplantation, University of Kansas Medical Center, Kansas City, USA.
Diane M CibrikCenter for Transplantation, University of Kansas Medical Center, Kansas City, USA.
David DrewDivision of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
Mark SarnakDivision of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
University of Kansas Medical Center · USTufts Medical Center · US

Funding

Cognitive Impairment in End Stage Renal DiseaseK23AG055666 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUPTA, ADITI · 2017 to 2022
$1.2M
NIA NIH HHS K23 AG055666NIH HHS K23-AG055666
6 · The paper itself

Abstract

introductionTransplant centers hesitate to transplant patients with cognitive impairment. It is unclear if pre-kidney transplant (KT) cognitive screening can predict post-KT cognitive function.

methodsWe evaluated pre- to post-KT cognitive function with the Montreal Cognitive Assessment (MoCA) in a cohort of 108 patients. We used an adjusted logistic regression model to assess pre- to post-KT changes in cognitive status (continuous variable) and a linear mixed model to assess changes in MoCA scores (categorical variable) pre- to post- KT.

resultsThe average pre- and post-KT MoCA scores were 25.3 ± 3.0 and 26.4 ± 2.8, respectively. Final pre-KT score did not predict post-KT cognitive status (OR = 1.08; 95% CI: .92-1.26; P = .35). 32% of the patients with a final pre-KT score ≥26 had at least one post-KT score < 26. Conversely, 61% of the patients with a final pre-KT score < 26 had at least one post KT score ≥26. In the linear mixed model analysis, the final pre-KT score was associated with a small, clinically insignificant (β = .34; 95% CI: .19-.49; P < .001) effect on the post-KT score.

conclusionA low pre-KT MoCA score is not a strong independent predictor of post-KT cognitive function and should not preclude patients from receiving a KT.

Indexed as

Cognitive DysfunctionKidney TransplantationCognitionHumanscognitionend stage kidney diseasekidney transplantationMoCAtransplant eligibility

Identifiers

PMID35989467
PMCPMC10691449
OpenAlexW4292567079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.