ArticleAngewandte Chemie (International ed. in English)2022
Fast-Scan Cyclic Voltammetry (FSCV) Reveals Behaviorally Evoked Dopamine Release by Sugar Feeding in the Adult Drosophila Mushroom Body.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements.Biosensors · 2026Article
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision-Related Neuronal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Boron-Doped Nano-Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing.Advanced healthcare materials · 2026Article
- Recent Advances in Flexible Sensors for Neural Interfaces: Multimodal Sensing, Signal Integration, and Closed-Loop Feedback.Biosensors · 2025Review
- Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates.ACS chemical neuroscience · 2025Article
- Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons.eLife · 2025Article
- Article
- Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals.Biosensors · 2024Review
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents.Biosensors & bioelectronics · 2023Article
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents.bioRxiv : the preprint server for biology · 2023Article
- Fast-Scan Cyclic Voltammetry (FSCV) Reveals Behaviorally Evoked Dopamine Release by Sugar Feeding in the Adult Drosophila Mushroom Body.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Drosophila melanogaster, the fruit fly, is an excellent model organism for studying dopaminergic mechanisms and simple behaviors, but methods to measure dopamine during behavior are needed. Here, we developed fast-scan cyclic voltammetry (FSCV) to track in vivo dopamine during sugar feeding. First, we employed acetylcholine stimulation to evaluate the feasibility of in vivo measurements in an awake fly. Next, we tested sugar feeding by placing sucrose solution near the fly proboscis. In the mushroom body medial tip, 1 pmol acetylcholine and sugar feeding released 0.49±0.04 μM and 0.31±0.06 μM dopamine, respectively but sugar-evoked release lasted longer than with acetylcholine. Administering the dopamine transporter inhibitor nisoxetine or D2 receptor antagonist flupentixol significantly increased sugar-evoked dopamine. This study develops FSCV to measure behaviorally evoked release in fly, enabling Drosophila studies of neurochemical control of reward, learning, and memory behaviors.
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