Evidence map›Paper›PMID 35989402›Full record

ArticleBiological trace element research2023

Magnesium Depletion Score Predicts Diabetic Retinopathy Risk among Diabetes: Findings from NHANES 2005-2018.

Yuan Chen, Xiaoli Xiang, Yangyang Wu, Shaojie Han, Zhengru Huang, Miaoqin Wu

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06891846 (Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06891846 completednot on this mapstarted 2025, after this paper: background citation

Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction

Typeobservational_patient_registrySponsorSaglik Bilimleri UniversitesiRan2025 to 2025Enrolled111ConditionsWound Healing, Magnesium Level, Wisdom Tooth Removal
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yuan ChenSoochow University, 215031, Suzhou, China.
Xiaoli XiangDepartment of Ophthalmology, Changshu No. 2 People's Hospital, Changshu, 215500, China.
Yangyang WuDepartment of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
Shaojie HanGushu College, Nanjing Medical University, Nanjing, 211166, China.
Zhengru HuangDepartment of Ophthalmology, Changshu No. 2 People's Hospital, Changshu, 215500, China. hzru@sina.com.
Miaoqin WuSoochow University, 215031, Suzhou, China. eyewmq@126.com.
Changshu No.1 People's Hospital · CNSoochow University · CNBengbu Medical College · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium is essential for material and energy metabolism. The magnesium depletion score (MDS) is recognized as a more valuable and reliable predictor of body magnesium status than any other clinical used markers such as serum and urine magnesium. However, research on the relationship between MDS and diabetic retinopathy (DR) is limited. As a result, the current study sought to assess this issue in diabetic samples from a large population-based database in the United States. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. MDS was calculated, and multivariate logistic regression analysis was applied to evaluate the presence of association between variables and DR risk. A total of 4308 participants was comprised in this study. Samples with DR consumed less magnesium (259.1 ± 113.6 vs 269.8 ± 113.2 mg, P < 0.001), and their MDS levels differed significantly from non-DR participants (P < 0.001). Increased dietary magnesium was linked to a lower incidence of DR (all P for trend < 0.05), and patients with a high level of MDS were more prone to DR (P = 0.001). Furthermore, subgroup analysis revealed that high (Q3) amount magnesium supplements was associated with lower DR risk when MDS was none to low or middle level (both P = 0.02). Our results indicated that MDS levels are associated with DR risk and that magnesium supplementation is benefit to DR prevention.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyBiomarkersHumansMagnesiumNutrition SurveysRisk FactorsBiomarkersMagnesiumDiabetes mellitus (DM)Diabetic retinopathy (DR)MagnesiumMagnesium depletion score (MDS)

Identifiers

PMID35989402
PMCPMC10073168
OpenAlexW4292679870

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.