SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2023
Management of juvenile and aneurysmal bone cysts: a systematic literature review with meta-analysis.
Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Gelified ethanol for percutaneous sclerotherapy of bone lesions: a systematic review of clinical applications and outcomes.Skeletal radiology · 2026Pooled it
- [Surgical management of juvenile and aneurysmal bone cysts in children and adolescents : Curettage, ceramic bone graft substitution and adjuvants].Operative Orthopadie und Traumatologie · 2026Trial
- Analysis of risk factors for postoperative wound healing in children with bone cysts.Annals of medicine · 2026Article
- Non-Oncological Progression of an Aneurysmal Bone Cyst (ABC) in a Puppy Following Surgical Treatment.Animals : an open access journal from MDPI · 2026Article
- Use of Fibrin Sealant Combined With Demineralized Freeze-Dried Bone Allograft in the Management of a Recurrent Mandibular Aneurysmal Bone Cyst: A Case Report.Clinical case reports · 2026Article
- Unicameral Bone Cyst: Diagnosis, Treatment, and Follow-Up Methods, a Multicenter Study.Medicina (Kaunas, Lithuania) · 2026Article
- Transphyseal Proximal Humeral Aneurysmal Bone Cyst with Pathologic Fracture in a Child: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- The most common bone tumors of the upper extremity in childhood and adolescence and their treatment: a review of the current literature.EFORT open reviews · 2026Review
- The best solution is the simplest: advances in surgical and minimally invasive management of aneurysmal and simple bone cysts.Journal of orthopaedic surgery and research · 2026Review
- Surgically Treated Benign Bone Tumors and Tumor-like Conditions in the Pediatric Population-A 10-Year Institutional Experience.Children (Basel, Switzerland) · 2025Article
- Aneurysmal bone cysts (ABC): Retrospective analysis of two hundred and fifty eight cases.International orthopaedics · 2025Article
- Exploring Aneurysmal Bone Cysts of the Skull: Insights from a Review of the Literature and a Case Report.Children (Basel, Switzerland) · 2025Review
- Curettage and bone grafting combined with electrocautery and drill, supplemented with plate fixation for the treatment of pediatric humeral aneurysmal bone cysts: a retrospective study.Frontiers in pediatrics · 2025Article
- Infantile Aggressive Aneurysmal Bone Cyst of the Proximal Femur: A Rare Clinical Presentation.Cureus · 2024Article
- How Arterial Embolization Is Transforming Treatment of Oncologic and Degenerative Musculoskeletal Disease.Current oncology (Toronto, Ont.) · 2024Review
- Response of Recurrent Aggressive Aneurysmal Bone Cyst of Distal Tibia to Denosumab Treatment.Journal of orthopaedic case reports · 2024Article
- Acetabular Aneurysmal Bone Cyst During the Syrian Conflict: A Case Report of Surgical Treatment and Outcomes.Cureus · 2024Article
- Efficacy of Percutaneous Treatment of Primary Aneurysmal Bone Cysts (ABCs): A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Aneurysmal Bone Cyst of the Pelvis in Children and Adolescents: Effectiveness of Surgical Treatment with Curettage, Cryotherapy and Bone Grafting.Healthcare (Basel, Switzerland) · 2023Article
- Single dose intralesional doxycycline foam infusion promotes bone growth and resolution of an odontoid aneurysmal bone cyst.Surgical neurology international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNumerous approaches to the management of juvenile and aneurysmal bone cysts (ABC) are described in the specialist literature together with discussion of the associated healing and recurrence rates. Since there is currently no evidence-based treatment standard for these conditions, the aim of this systematic literature review with meta-analysis was to examine the different management approaches, evaluate the corresponding clinical outcomes and, as appropriate, to formulate a valid treatment recommendation.
methodsA systematic search on OVID Medline
resultsFor aneurysmal bone cysts, both surgical removal and Doxycycline injection lead to excellent outcomes (98% healing) and low recurrence rates (6% and 11% resp.). Curettage (91% healing), including its combination with autologous cancellous bone graft (96% healing), showed very good healing rates but higher recurrence rates (22% and 15%, resp.), which were however improved by preoperative selective arterial embolization. A critical view must be taken of radiotherapy (90% healing) and the injection of alcohol (92% healing) because of their high complication rates (0.43/cyst and 0.42/cyst, resp.). In the management of juvenile bone cysts, surgical interventions like curettage and cancellous bone graft (87% healing) are far superior to non-surgical approaches (51% healing), furthermore, the application of autologous cancellous bone graft reduced the recurrence rate (3% recurrence) compared to curettage alone (20% recurrence). In subgroup analysis, treatment by ESIN was found to produce excellent outcomes (100% healing), though the patient collectives were small.
conclusionSurgical procedures to treat aneurysmal bone cysts appear to be the method of choice whereby Doxycycline injection may be an alternative. A surgical approach should be preferred in the treatment of juvenile bone cysts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.