Evidence map›Paper›PMID 35989335›Full record

ArticleCell & bioscience2022

CDKN2AIP is critical for spermiogenesis and germ cell development.

Yuming Cao, Qi Sun, Zhenlie Chen, Jing Lu, Ting Geng, Ling Ma, Yuanzhen Zhang

Open access · goldAbstract read
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Frontiers in genetics · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuming CaoReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qi SunHubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430070, Hubei, People's Republic of China.
Zhenlie ChenReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jing LuDepartment of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, People's Republic of China.
Ting GengReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ling MaReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China. 461825481@qq.com.
Yuanzhen ZhangReproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China. zhangyuanzhen@whu.edu.cn.ORCID http://orcid.org/0000-0001-5393-290X
Wuhan University · CN

Funding

Hubei Science and Technology Plan 2017ACB640Institute of Heavy Rain, China Meteorological Administration TFJC2018001
6 · The paper itself

Abstract

backgroundAs a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation. Recent studies indicate that Cdkn2aip is essential for spermatogonial self-renewal and proliferation through the activating Wnt-signaling pathway. However, the mechanisms of how Cdkn2aip regulate spermatogenesis is poorly characterized.

resultsWe discovered that the CDKN2AIP was expressed in spermatocyte as well as spermatids and participated in spermiogenesis. Cdkn2aip

conclusionsOur findings not only identified the importance of CDKN2AIP in spermiogenesis and germ cell development, but also provided insight upon the driving mechanism.

Indexed as

DNA double-strand break repairGerm cell developmentMale infertilityProtamine replacementSpermiogenesis

Identifiers

PMID35989335
PMCPMC9394077
OpenAlexW4294315149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.