Evidence map›Paper›PMID 35988792›Full record

ReviewPharmacology, biochemistry, and behavior2022

Advances in translating mGlu

Ryan E Tyler, Joyce Besheer, Max E Joffe

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacology, biochemistry, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy.Frontiers in bioscience (Landmark edition) · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ryan E TylerBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, USA.
Joyce BesheerBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, USA.
Max E JoffeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Translational Neuroscience Program, University of Pittsburgh, USA. Electronic address: joffeme@upmc.edu.
University of North Carolina at Chapel Hill · USUniversity of Pittsburgh · US

Funding

Characterization of alcohol self-administration following predator odor exposure: relevance to PTSD-Diversity SupplementR01AA026537 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joyce Besheer · 2017 to 2026
$3.9M
Sex differences in fast-spiking interneurons promote AUD-related PFC dysfunction: remediation by modulating mGlu1 and mGlu5 - Supplement RevR00AA027806 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOFFE, MAX E · 2021 to 2023
$826k
Sex differences in fast-spiking interneurons promote AUD-related PFC dysfunction: remediation by modulating mGlu1 and mGlu5K99AA027806 · NIAAA · VANDERBILT UNIVERSITY · PI JOFFE, MAX E · 2020 to 2021
$276k
The early and lasting mechanisms underlying predator odor stressor-induced adaptations to alcohol interoceptive sensitivityF31AA029946 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TYLER, RYAN EDWARD · 2022 to 2023
$57k
NIAAA NIH HHS F31 AA029946NIAAA NIH HHS K99 AA027806NIAAA NIH HHS R00 AA027806NIAAA NIH HHS R01 AA026537
6 · The paper itself

Abstract

Metabotropic glutamate (mGlu) receptors are promising targets for the treatment of affective disorders and alcohol use disorder (AUD). Nonspecific ligands for Group II (mGlu

Indexed as

AlcoholismGlutamic AcidAnimalsHumansMiceMice, KnockoutMood DisordersSynaptic TransmissionGlutamic AcidDrug discoveryElectrophysiologyGene expressionG protein-coupled receptorPrelimbic cortexSynaptic plasticity

Identifiers

PMID35988792
PMCPMC10405528
OpenAlexW4292212684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.