Evidence map›Paper›PMID 35988043›Full record

ArticleClinical and experimental dermatology2022

Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis.

Fernando Valenzuela, Claudia De La Cruz, Cristóbal Lecaros, Javier Fernández, Gonzalo Hevia, Lara Valeska Maul, Jacob P Thyssen, Cristián Vera-Kellet, Alexander Egeberg, Daniela Armijo and 9 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Clinical and experimental dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07634016 (Global Healthcare Study on Psoriasis), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07634016 recruitingnot on this mapstarted 2025, after this paper: background citation

Global Healthcare Study on Psoriasis

Typeobservational_patient_registrySponsorJulia Tatjana MaulRan2025 to 2029Enrolled9,600ConditionsPsoriasis (PsO)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 6 countries.

Fernando ValenzuelaDepartment of Dermatology, University of Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-1032-9347
Claudia De La CruzClínica Dermacross, Santiago, Chile.
Cristóbal LecarosDepartment of Dermatology, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.ORCID https://orcid.org/0000-0002-8509-1188
Javier FernándezCentro Internacional de Estudios Clínicos, Probity Medical Research, Santiago, Chile.ORCID https://orcid.org/0000-0002-7110-3600
Gonzalo HeviaDepartment of Dermatology, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Lara Valeska MaulDepartment of Dermatology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0001-9202-0073
Jacob P ThyssenDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Cristián Vera-KelletDepartment of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-8697-9245
Alexander EgebergDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8257-1816
Daniela ArmijoClínica Dermacross, Santiago, Chile.
Cristian PizarroDepartment of Dermatology, Universidad Austral Campus Osorno, Osorno, Chile.
Tatiana RiverosDepartment of Dermatology, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.
Hernán CorreaCentro Dermatológico DERMAMED, Santiago, Chile.
Antonio GuglielmettiDepartment of Dermatology, Universidad de Valparaíso, Valparaíso, Chile.
Johannes A DidaskaluFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Jashin J WuDepartment of Dermatology, University of Miami Miller School of Medicine, Miami, FL, USA.
Christopher E M GriffithsDermatology Centre, Salford Royal Hospital, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0001-5371-4427
Ricardo RomitiDepartment of Dermatology, University of São Paulo, School of Medicine, São Paulo, Brazil.
Julia-Tatjana MaulFaculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-9914-1545
Universidad del Desarrollo · CLDermacross · CLUniversity of Copenhagen · DKUniversity of Zurich · CHAustral University of Chile · CLCentro de Estudios Científicos · CLComplejo Asistencial Sótero del Río · CLManchester Academic Health Science Centre · GBPontificia Universidad Católica de Chile · CLUniversidade de São Paulo · BRUniversity Hospital of Basel · CHUniversity of Chile · CLUniversity of Miami · USUniversity of Valparaíso · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.

aimTo examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.

methodsThis was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.

resultsIn total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.

conclusionsWe report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.

Indexed as

Diabetes Mellitus, Type 2DyslipidemiasNon-alcoholic Fatty Liver DiseasePsoriasisChileComorbidityCross-Sectional StudiesDelivery of Health CareFemaleHumansMaleObesity

Identifiers

PMID35988043
PMCPMC10092698
OpenAlexW4292509748

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.