Evidence map›Paper›PMID 35987931›Full record

ArticleNano-micro letters2022

Importance of Standardizing Analytical Characterization Methodology for Improved Reliability of the Nanomedicine Literature.

Shahriar Sharifi, Nouf N Mahmoud, Elizabeth Voke, Markita P Landry, Morteza Mahmoudi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano-micro letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Toxicity of nanostructures in drug delivery applications.Pharmaceutical science advances · 2026
    Review
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  4. Review
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  7. Review
  8. Review
  9. Article
  10. Engineered MoSNanomaterials (Basel, Switzerland) · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Biocompatible Thin Films Deposited by Laser Techniques.Materials (Basel, Switzerland) · 2026
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shahriar Sharifi *Department of Radiology and Precision Health Program, Michigan State University, East Lansing, MI, USA.
Nouf N Mahmoud *Department of Radiology and Precision Health Program, Michigan State University, East Lansing, MI, USA.
Elizabeth VokeDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA. landry@berkeley.edu.
Morteza MahmoudiDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, MI, USA. mahmou22@msu.edu.

Funding

A Nanostructured Skin Patch to Heal Chronic WoundsR01DK131417 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Morteza Mahmoudi · 2022 to 2026
$2.0M
NIDDK NIH HHS R01 DK131417
6 · The paper itself

Abstract

Understanding the interaction between biological structures and nanoscale technologies, dubbed the nano-bio interface, is required for successful development of safe and efficient nanomedicine products. The lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine literature. As such, there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical translation. Here, we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as pharmaceuticals. We also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical practice. We, however, emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.

Indexed as

CharacterizationNanomedicineNanomedicine devicesReproducibilityStandard protocols

Identifiers

PMID35987931
PMCPMC9392440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.