ArticleThe ISME journal2022
Metabolic adaptation to vitamin auxotrophy by leaf-associated bacteria.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Thiamine cross-feeding drives microbial coexistence in the leaf microbiome.Nature microbiology · 2026Article
- Cross-feeding enables robust coexistence between four bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adaxial-abaxial leaf surface asymmetry is a key ecological driver of the phyllosphere microbiome.Journal of experimental botany · 2026Article
- Bacterial degradation of a plant toxin and nutrient competition with commensals trade off to constrain pathogen growth.mSystems · 2026Article
- Metabolic feedbacks drive population dynamics and can lead to oscillations among leaf bacteria.Nature communications · 2026Article
- Ectomycorrhizal fungi recruit hyphae-associated bacteria that metabolize thiamine to promote pine symbiosis.The ISME journal · 2026Article
- eMZed 3: flexible and interactive development of scalable LC-MS/MS data analysis workflows in python.Bioinformatics advances · 2026Article
- Potentiators empower synthetic microbiomes as silent guardians against co-contamination.Nature communications · 2025Article
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- Seed-borne bacteria drive wheat rhizosphere microbiome assembly via niche partitioning and facilitation.Nature microbiology · 2025Article
- ComammoxiMeta · 2025Article
- Low functional change despite high taxonomic turnover characterizes theScience advances · 2025Article
- Vitamin auxotrophies shape microbial community assembly on model marine particles.The ISME journal · 2025Article
- Evaluating agar-plating and dilution-to-extinction isolation methods for generating oak-associated microbial culture collections.ISME communications · 2025Article
- Adjusted bacterial cooperation in anammox community to adapt to high ammonium in wastewater treatment plant.Water research X · 2024Article
- Exploring the enzymatic repertoires of Bacteria and Archaea and their associations with metabolic maps.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- New-to-nature CONature communications · 2024Article
- Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code.Nucleic acids research · 2024Article
- Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling.Nature communications · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxotrophs are unable to synthesize all the metabolites essential for their metabolism and rely on others to provide them. They have been intensively studied in laboratory-generated and -evolved mutants, but emergent adaptation mechanisms to auxotrophy have not been systematically addressed. Here, we investigated auxotrophies in bacteria isolated from Arabidopsis thaliana leaves and found that up to half of the strains have auxotrophic requirements for biotin, niacin, pantothenate and/or thiamine. We then explored the genetic basis of auxotrophy as well as traits that co-occurred with vitamin auxotrophy. We found that auxotrophic strains generally stored coenzymes with the capacity to grow exponentially for 1-3 doublings without vitamin supplementation; however, the highest observed storage was for biotin, which allowed for 9 doublings in one strain. In co-culture experiments, we demonstrated vitamin supply to auxotrophs, and found that auxotrophic strains maintained higher species richness than prototrophs upon external supplementation with vitamins. Extension of a consumer-resource model predicted that auxotrophs can utilize carbon compounds provided by other organisms, suggesting that auxotrophic strains benefit from metabolic by-products beyond vitamins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.