ArticleNature communications2022
Designing isolation guidelines for COVID-19 patients with rapid antigen tests.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- How are countries responding differently to COVID-19: a systematic review of guidelines on isolation measures.Frontiers in public health · 2023Pooled it
- Impact of Digital Contact Tracing and Other Nonpharmaceutical Interventions on Pandemic Control: Microlevel, Behavior-Driven Agent-Based Model Analysis.Journal of medical Internet research · 2026Article
- Identifying the optimal rapid antigen test for screening and determining the end of isolation: A modeling study.PLoS computational biology · 2026Article
- VIBES: A multiscale modeling approach integrating within-host and between-hosts dynamics in epidemics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Preemptive rapid antigen test as an emergency measure during coronavirus disease 2019 outbreaks.Frontiers in public health · 2026Article
- AI-Enabled Microfluidics for Respiratory Pathogen Detection.Sensors (Basel, Switzerland) · 2025Review
- Evaluating the effectiveness of international travel controls to identify MPXV-infected travelers: a simulation study.BMC medicine · 2025Article
- Modeling Antibody Kinetics Post-mRNA Booster Vaccination and Protection Durations Against SARS-CoV-2 Infection.Journal of medical virology · 2025Article
- Age- and vaccination status-dependent isolation guidelines based on simulation of SARS-CoV-2 Delta cases in Singapore.Communications medicine · 2025Article
- A modeling study to define guidelines for antigen screening in schools and workplaces to mitigate COVID-19 outbreaks.Communications medicine · 2025Article
- Impact of the COVID-19 pandemic on the consumption of antibiotics and the emergence of AMR: case study in a general hospital.Frontiers in public health · 2025Article
- Defining the Critical Requisites for Accurate Simulation of SARS-CoV-2 Viral Dynamics: Patient Characteristics and Data Collection Protocol.Journal of medical virology · 2025Article
- Article
- Modelling the effectiveness of an isolation strategy for managing mpox outbreaks with variable infectiousness profiles.Nature communications · 2024Article
- Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis.Experimental & molecular medicine · 2024Article
- The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study.Scientific reports · 2024Article
- Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution.Nature communications · 2023Article
- Analysis of the risk and pre-emptive control of viral outbreaks accounting for within-host dynamics: SARS-CoV-2 as a case study.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Enhancing a SARS-CoV-2 nucleocapsid antigen test sensitivity with cost efficient strategy through a cotton intermembrane insertion.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Appropriate isolation guidelines for COVID-19 patients are warranted. Currently, isolating for fixed time is adopted in most countries. However, given the variability in viral dynamics between patients, some patients may no longer be infectious by the end of isolation, whereas others may still be infectious. Utilizing viral test results to determine isolation length would minimize both the risk of prematurely ending isolation of infectious patients and the unnecessary individual burden of redundant isolation of noninfectious patients. In this study, we develop a data-driven computational framework to compute the population-level risk and the burden of different isolation guidelines with rapid antigen tests (i.e., lateral flow tests). Here, we show that when the detection limit is higher than the infectiousness threshold values, additional consecutive negative results are needed to ascertain infectiousness status. Further, rapid antigen tests should be designed to have lower detection limits than infectiousness threshold values to minimize the length of prolonged isolation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.