Evidence map›Paper›PMID 35987120›Full record

ArticleStem cell research2022

Generation of an induced pluripotent stem cell line NCHi003-A from a 11-year-old male with pulmonary atresia with intact ventricular septum (PA-IVS).

Javier Contreras, Matthew Alonzo, Shiqiao Ye, Hui Lin, Lumariz Hernandez-Rosario, Kim L McBride, Karen Texter, Vidu Garg, Ming-Tao Zhao

Open access · goldAbstract readCase Reports
In one paragraph

Article in Stem cell research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Javier ContrerasCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, OH 43210, United States.
Matthew AlonzoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States.
Shiqiao YeCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States.
Hui LinCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States.
Lumariz Hernandez-RosarioCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States.
Kim L McBrideCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, United States.
Karen TexterThe Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, United States.
Vidu GargCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, United States.
Ming-Tao ZhaoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, United States; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, United States; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, OH 43210, United States; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, United States. Electronic address: mingtao.zhao@nationwidechildrens.org.
Nationwide Children's Hospital · USThe Ohio State University · US

Funding

An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and diseaseR01HL155282 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mingtao Zhao · 2021 to 2026
$3.2M
NHLBI NIH HHS R01 HL155282
6 · The paper itself

Abstract

Pulmonary atresia with intact ventricular septum (PA-IVS) is a rare congenital heart defect defined by membranous or muscular atresia of the right ventricular outflow tract where patients display varying degrees of hypoplasia of the right ventricle. This condition results in cyanosis due to an inability of blood to flow from the right ventricle to the pulmonary arteries, thus requiring immediate surgical intervention after birth. An iPSC line was generated from peripheral blood mononuclear cells of a 11-year-old male patient diagnosed with PA-IVS through Sendai virus-mediated reprogramming. This disease-specific iPSC line was characterized by immunocytochemistry, STR analysis, karyotype analysis, and mycoplasma testing.

Indexed as

Heart Defects, CongenitalInduced Pluripotent Stem CellsPulmonary AtresiaChildHumansLeukocytes, MononuclearMale

Identifiers

PMID35987120
PMCPMC9629876
OpenAlexW4292425661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.