Evidence map›Paper›PMID 35986828›Full record

ArticleBiochemical genetics2023

A Study of Combined Genotype Effects of SHCBP1 on Wool Quality Traits in Chinese Merino.

Guang-Wei Ma, Shou-Zhi Wang, Ning Wang, Hui Li, Hua Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Guang-Wei MaMinistry of Education, Key Laboratory for Ecology of Tropical Islands; Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou, 571158, People's Republic of China.
Shou-Zhi WangKey Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Ning WangKey Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Hui LiKey Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Hua YangState Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, 832000, People's Republic of China. yhxjcn@sina.com.ORCID http://orcid.org/0000-0003-4993-7796
Northeast Agricultural University · CNHainan Normal University · CNXinjiang Academy of Agricultural and Reclamation Science · CN

Funding

Major Scientific and Technological Project of the Xinjiang Production and Construction Corps No. 2017AA006Young and Middle-aged Scientific and Technological Innovation Leading Talent Plan of the Xinjiang Production and Construction Corps No. 2019CB019Young and Middle-aged Talents Training and Guidance Plan of State Key Laboratory of Sheep Genetic Improvement and Healthy Production No. SKLSGIHP2016A01
6 · The paper itself

Abstract

SHCBP1 (Shc SH2-domain binding protein 1) is a member of the Src and collagen homolog (Shc) protein family and is closely associated with multiple signaling pathways that play important roles during hair follicle induction, morphogenesis, and cycling. The purpose of this study was to investigate SHCBP1 gene expression, polymorphisms, and the association between SHCBP1 and wool quality traits in Chinese Merino sheep. The SHCBP1 gene was shown, by qPCR, to be ubiquitously expressed in sheep tissues and differentially expressed in the adult skin of Chinese Merino and Suffolk sheep. Four SNPs (termed SHCBP1SNPs 1-4) were identified by Sanger sequencing and were located in exon 2, intron 9, intron 12, and exon 13 of the sheep SHCBP1 gene, respectively. SHCBP1SNPs 3 and 4 (rs411176240 and rs160910635) were significantly associated with wool crimp (P < 0.05). The combined polymorphism (SHCBP1SNP3-SHCBP1SNP4) was significantly associated with wool crimp (P < 0.05). Bioinformatics analysis showed that the SNPs associated with wool crimp (SHCBP1SNPs 3 and 4) might affect the pre-mRNA splicing by creating binding sites for serine-arginine-rich proteins and that SHCBP1SNP4 might alter the SHCBP1 mRNA and protein secondary structure. Our results suggest that SHCBP1 influences wool crimp and SHCBP1SNPs 3 and 4 might be useful markers for marker-assisted selection and sheep breeding.

Indexed as

Shc Signaling Adaptor ProteinsSheepWoolAnimalsGenotypePhenotypePolymorphism, Single NucleotideShc Signaling Adaptor ProteinsSHCBP1SNPTissue expressionWool crimp

Identifiers

PMID35986828
OpenAlexW4292475222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.