Evidence map›Paper›PMID 35986586›Full record

ArticlePsycho-oncology2022

Longitudinal investigation of suicidal ideation and associated factors during pediatric acute lymphoblastic leukemia chemotherapy.

Kimberly P Raghubar, Tiffany Chambers, Ryan M Hill, Olga Taylor, Marilyn Hockenberry, M Casey Hooke, Pauline Mitby, Ida Ki Moore, Austin L Brown, Michael E Scheurer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psycho-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kimberly P RaghubarDepartment of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9332-181X
Tiffany ChambersDepartment of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
Ryan M HillDepartment of Psychology, College for Health, Community and Policy, University of Texas at San Antonio, San Antonio, Texas, USA.
Olga TaylorDepartment of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
Marilyn HockenberryDepartment of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
M Casey HookeSchool of Nursing, University of Minnesota, Minneapolis, Minnesota, USA.
Pauline MitbyChildren's Minnesota Cancer and Blood Disorders Program, Minneapolis, Minnesota, USA.
Ida Ki MooreDepartment of Nursing, University of Arizona, Tuscan, Arizona, USA.
Austin L BrownDepartment of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.
Michael E ScheurerDepartment of Pediatrics, Section of Oncology, Baylor College of Medicine, Houston, Texas, USA.

Funding

Phenotype-Genotype Associations with Symptoms During Childhood Leukemia TreatmentR01CA169398 · NCI · DUKE UNIVERSITY · PI HOCKENBERRY, MARILYN J, SCHEURER, MICHAEL E. · 2012 to 2016
$2.9M
Integrative Molecular Epidemiology of Neurocognitive Outcomes in Acute Lymphoblastic LeukemiaK07CA218362 · NCI · BAYLOR COLLEGE OF MEDICINE · PI BROWN, AUSTIN L · 2018 to 2022
$758k
NCI NIH HHS K07 CA218362NCI NIH HHS R01 CA169398NIH HHS K07 CA 218362NIH HHS R01 CA 1693398
6 · The paper itself

Abstract

objectiveThis study describes the prevalence of suicidal ideation (SI) during acute lymphoblastic leukemia (ALL) therapy and investigates the influence of clinical factors and physical symptoms on SI.

methodsThe Children's Depressive Inventory (CDI-2) was administered to ALL patients (diagnosed 2012-2017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi-site study. SI was present if patients endorsed the item "I want to kill myself." Logistic regression models evaluated associations between SI and sociodemographic factors; depressive symptoms; and below average, average, and above average symptom clusters identified using latent class analysis of pain, nausea, fatigue, and sleep.

resultsParticipants (n = 175) were 51% male, 75% high-/very high-risk disease, with a median age of 11.2 years at diagnosis (range: 7-18 years). Overall, 14.9% of patients (75% under age 12 years) endorsed SI during treatment, including 4% at start of consolidation, 9% at DI, 8% at MC1, and 4% at MC2. Non-Hispanic Other patients were 10.9-times (95% CI: 2.30-53.40) more likely than non-Hispanic Whites to endorse SI (p = 0.003). The frequency of SI was higher in patients experiencing above average (53.3%) compared to below average (4.1%, p = 0.003) symptoms. Depressive symptoms were consistently associated with SI.

conclusionsSI during the initial year of childhood ALL was more prevalent in children under the age of 12 years, from ethnic groups not typically associated with increased risk, and who endorsed increased physical and depressive symptoms. Findings highlight the need for improved screening of mental health problems to mitigate symptoms of distress.

Indexed as

Precursor Cell Lymphoblastic Leukemia-LymphomaSuicidal IdeationAdolescentChildDepressionFemaleHumansLatent Class AnalysisMalePainPrevalenceRisk Factorsadolescentcancerchilddepressionfatiguenauseaoncologypainpsycho-oncologysleep

Identifiers

PMID35986586
PMCPMC10754031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.