Evidence map›Paper›PMID 35986432›Full record

ArticleCell & bioscience2022

Melatonin inhibits NaIO

Kai Wang, Yong-Syuan Chen, Hsiang-Wen Chien, Hui-Ling Chiou, Shun-Fa Yang, Yi-Hsien Hsieh

Open access · goldAbstract read
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  3. MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD.In vitro cellular & developmental biology. Animal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kai Wang *Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.
Yong-Syuan Chen *Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hsiang-Wen ChienDepartment of Ophthalmology, Cathay General Hospital, Taipei, Taiwan.
Hui-Ling ChiouDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan. ysf@csmu.edu.tw.
Yi-Hsien HsiehInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan. hyhsien@csmu.edu.tw.ORCID http://orcid.org/0000-0003-4942-1888
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWFu Jen Catholic University · TW

Funding

Ministry of Science and Technology, Taiwan 110-2320-B-040-005-MY3
6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the role it plays in AMD remains unclear. Herein, we investigated the anti-AMD molecular mechanism of melatonin after sodium iodate (NaIO3) treatment of ARPE-19 cells in vitro and in animal models with the goal of improving the therapeutic effect.

resultsThe in vitro results showed that melatonin protected against NaIO

conclusionsThese results indicate that melatonin attenuated NaIO

Indexed as

Age-related macular degenerationBNIP3HIF-1αLC3BMelatoninMitophagyRetinal pigment epithelial cells

Identifiers

PMID35986432
PMCPMC9389659
OpenAlexW4292367306

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.