Evidence map›Paper›PMID 35986384›Full record

ArticleAddiction science & clinical practice2022

Association between treatment setting and outcomes among oregon medicaid patients with opioid use disorder: a retrospective cohort study.

Daniel M Hartung, Sheila Markwardt, Kirbee Johnston, Jonah Geddes, Robin Baker, Gillian Leichtling, Christi Hildebran, Brian Chan, Ryan R Cook, Dennis McCarty and 2 more

Open access · goldAbstract read
In one paragraph

Article in Addiction science & clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Daniel M HartungOregon State University College of Pharmacy, Portland, OR, USA. hartungd@ohsu.edu.ORCID 0000-0002-0685-773X
Sheila MarkwardtOregon Health & Science University, Biostatistics and Design Program, Portland, OR, USA.
Kirbee JohnstonOregon State University College of Pharmacy, Portland, OR, USA.
Jonah GeddesPSU-OHSU School of Public Health, Portland, OR, USA.
Robin BakerPSU-OHSU School of Public Health, Portland, OR, USA.
Gillian LeichtlingComagine Health, Portland, OR, USA.
Christi HildebranComagine Health, Portland, OR, USA.
Brian ChanOregon Health & Science University, Section of Addiction Medicine, Portland, OR, USA.
Ryan R CookOregon Health & Science University, Section of Addiction Medicine, Portland, OR, USA.
Dennis McCartyPSU-OHSU School of Public Health, Portland, OR, USA.
Udi GhitzaNational Institute On Drug Abuse (NIDA), Center for the Clinical Trials Network (CCTN), Bethesda, ML, USA.
P Todd KorthuisPSU-OHSU School of Public Health, Portland, OR, USA.
Oregon Health & Science University · USUniversity of Portland · USNational Institute on Drug Abuse · USOregon State University · USPortland State University · US

Funding

Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Oregon HIV/Hepatitis and Opioid Prevention and Engagement (OR-HOPE) Study Cost ExtensionUH3DA044831 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2019 to 2022
$4.0M
Oregon HIV/Hepatitis and Opioid Prevention and Engagement (OR-HOPE) StudyUG3DA044831 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2017 to 2018
$895k
Identifying High Utilizing Patients with Opioid Use Disorder to Engage in Primary CareK23DA053390 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Brian Chan · 2022 to 2026
$886k
NIDA NIH HHS K23 DA053390NIDA NIH HHS UG1 DA015815NIDA NIH HHS UG3 DA044831NIDA NIH HHS UH3 DA044831
6 · The paper itself

Abstract

backgroundResidential treatment is a common approach for treating opioid use disorder (OUD), however, few studies have directly compared it to outpatient treatment. The objective of this study was to compare OUD outcomes among individuals receiving residential and outpatient treatment.

methodsA retrospective cohort study used linked data from a state Medicaid program, vital statistics, and the Substance Abuse and Mental Health Services Administration (SAMHSA) Treatment Episodes Dataset (TEDS) to compare OUD-related health outcomes among individuals treated in a residential or outpatient setting between 2014 and 2017. Multivariable Cox proportional hazards and logistic regression models examined the association between treatment setting and outcomes (i.e., opioid overdose, non-overdose opioid-related and all-cause emergency department (ED) visits, hospital admissions, and treatment retention) controlling for patient characteristics, co-morbidities, and use of medications for opioid use disorders (MOUD). Interaction models evaluated how MOUD use modified associations between treatment setting and outcomes.

resultsOf 3293 individuals treated for OUD, 957 (29%) received treatment in a residential facility. MOUD use was higher among those treated as an outpatient (43%) compared to residential (19%). The risk of opioid overdose (aHR 1.39; 95% CI 0.73-2.64) or an opioid-related emergency department encounter or admission (aHR 1.02; 95% CI 0.80-1.29) did not differ between treatment settings. Independent of setting, MOUD use was associated with a significant reduction in overdose risk (aHR 0.45; 95% CI 0.23-0.89). Residential care was associated with greater odds of retention at 6-months (aOR 1.71; 95% CI 1.32-2.21) but not 1-year. Residential treatment was only associated with improved retention for individuals not receiving MOUD (6-month aOR 2.05; 95% CI 1.56-2.71) with no benefit observed in those who received MOUD (aOR 0.75; 95% CI 0.46-1.29; interaction p = 0.001).

conclusionsRelative to outpatient treatment, residential treatment was not associated with reductions in opioid overdose or opioid-related ED encounters/hospitalizations. Regardless of setting, MOUD use was associated with a significant reduction in opioid overdose risk.

Indexed as

BuprenorphineDrug OverdoseOpiate OverdoseOpioid-Related DisordersAnalgesics, OpioidHumansMedicaidOpiate Substitution TreatmentOregonRetrospective StudiesUnited StatesAnalgesics, OpioidBuprenorphineMedications for opioid use disorderOpioid use disorderResidential treatmentTreatment

Identifiers

PMID35986384
PMCPMC9389731
OpenAlexW4292373609

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.