Evidence map›Paper›PMID 35986369›Full record

ArticleJournal of experimental & clinical cancer research : CR2022

Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts.

Po-Ju Lee, Yun-Hua Sui, Tzu-Tung Liu, Ngan-Ming Tsang, Chen-Han Huang, Ting-Yi Lin, Kai-Ping Chang, Shu-Chen Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  5. Prostaglandin ECell death & disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Po-Ju Lee *Department of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan.
Yun-Hua Sui *Department of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan.
Tzu-Tung LiuDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan.
Ngan-Ming TsangDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan.
Chen-Han HuangDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan.
Ting-Yi LinDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan.
Kai-Ping ChangDepartment of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan. dr.kpchang@gmail.com.
Shu-Chen LiuDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist, Taoyuan City, 32001, Taiwan. jennyliu66@gmail.com.
National Central University · TWChang Gung Memorial Hospital · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe progression of nasopharyngeal carcinoma (NPC) is profoundly affected by Epstein-Barr virus (EBV) infection. However, the role of EBV in the intercommunication between NPC and surrounding stromal cells has yet to be explored.

methodsNPC biopsies were obtained for immunohistochemical (IHC) analyses. Clinical correlations between the expression of active YAP1/FAPα and the fibrotic response and between YAP1/FAPα and the density of cytotoxic CD8a

resultsNPC patients who developed metastasis had significantly higher levels of active YAP1 and FAPα in their tumor stroma, which was further correlated with tumor fibrosis and poorer metastasis-free survival. Exosomes released from EBV

conclusionEBV orchestrates interactions with the host and surrounding stroma by stimulating the functions of YAP1 and FAPα in fibroblasts through exosome cargos to create a more immunosuppressive, proinvasive microenvironment.

Indexed as

CarcinomaEpstein-Barr Virus InfectionsExosomesNasopharyngeal NeoplasmsAnimalsCytokinesEndopeptidasesFibroblast Activation Protein AlphaFibroblastsFibrosisHerpesvirus 4, HumanHumansMembrane ProteinsMiceNasopharyngeal CarcinomaTumor MicroenvironmentCytokinesEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsYAP1 protein, humanYAP-Signaling ProteinsEBVEpstein-Barr virusExosomeFAPαFibroblastFibroblast activation protein alphaFibrosisNasopharyngeal carcinomaNPCYAP1

Identifiers

PMID35986369
PMCPMC9392321
OpenAlexW4294048448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.