Evidence map›Paper›PMID 35986323›Full record

Trial reportReproductive biology and endocrinology : RB&E2022

A randomized double blind comparison of atosiban in patients with recurrent implantation failure undergoing IVF treatment.

Chuan Ling Tang, Qi Yue Li, Feng Lian Chen, Chen Ting Cai, Yue Yan Dong, Yuan Yuan Wu, Jian Zhi Yang, Mei Zhao, Feng Li Chi, Ling Hong and 5 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Reproductive biology and endocrinology : RB&E, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02893722 (A Randomized Double Blind Comparison of Atosiban in Patients With Repeated Implantation Failure Undergoing IVF Treatment), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02893722 phase1unknown statusnot on this map

A Randomized Double Blind Comparison of Atosiban in Patients With Repeated Implantation Failure Undergoing IVF Treatment

TypeinterventionalSponsorShanghai First Maternity and Infant HospitalRan2017 to 2018Enrolled200ConditionsRepeated Implantation FailureArmsatosiban, 0.9% saline
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Chuan Ling Tang *Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. ttangirl56@sina.com.
Qi Yue Li *Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Feng Lian ChenShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Chen Ting CaiShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yue Yan DongShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yuan Yuan WuShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jian Zhi YangShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Mei ZhaoShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Feng Li ChiShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Ling HongShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Ai AiShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Miao Xin ChenShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Kun Ming LiShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xiao Ming TengShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Zhi Qin ChenShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. ptchen1@hotmail.com.
Shanghai First Maternity and Infant Hospital · CN

Funding

National Natural Science Foundation of China 81971383Natural Science Foundation of Shanghai 17ZR1422000Special fund for clinical research of Chinese Medical Association 16020460662
6 · The paper itself

Abstract

backgroundPatients with recurrent implantation failure (RIF) may have more uterine contractions. Several observational studies suggested that atosiban administration around embryo transfer resulted in higher pregnancy rates in RIF patients. This study aimed to evaluate the effect of atosiban given before fresh embryo transfer on pregnancy outcomes of women with RIF.

methodsA prospective, randomized, double-blind controlled clinical trial was performed in IVF center of Shanghai First Maternity and Infant Hospital. According to a computer-generated randomization list, 194 infertile women with RIF received fresh embryo transfer between July 2017 and December 2019 were randomly allocated into the atosiban (n = 97) and the placebo (n = 97) groups. Women in the treatment group received atosiban intravenously about 30 min before embryo transfer with a bolus dose of 6.75 mg over one minute. Those in the placebo group received only normal saline infusion for the same duration.

resultsThere was no significant difference in the live birth rate between the atosiban and placebo groups (42.3% vs 35.1%, P = 0.302, RR = 1.206 (0.844-1.723)). No significant differences were found between the two groups in the positive pregnancy test, clinical pregnancy, ongoing pregnancy, miscarriage, multiple pregnancy, ectopic pregnancy and implantation rates. Similar results were found when stratified by the number of embryos previously transferred, number of previous failed embryo transfers, frequency of endometrial peristalsis on embryo transfer day (≥ 3 waves/min) or serum estradiol (E

conclusionsThese results suggested that atosiban treatment before fresh embryo transfer might not improve the live birth rate in RIF patients.

trial registrationThe study had been approved by the Institutional Review Board of the hospital (2017 ethics No.43) and was registered under Clinicaltrials.gov with an identifier NCT02893722.

Indexed as

Fertilization in VitroInfertility, FemaleChinaEmbryo ImplantationFemaleHumansLive BirthPregnancyPregnancy RateProspective StudiesVasotocinatosibanVasotocinAtosibanEndometrial peristalsisFresh embryo transferLive birth rateRecurrent implantation failure

Identifiers

PMID35986323
PMCPMC9389813
OpenAlexW4292335978

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.