Evidence map›Paper›PMID 35986291›Full record

ArticleBMC health services research2022

Reliability of predictive models to support early decision making in the emergency department for patients with confirmed diagnosis of COVID-19: the Pescara Covid Hospital score.

Ennio Polilli, Antonella Frattari, Jessica Elisabetta Esposito, Milena D'Amato, Giorgia Rapacchiale, Angela D'Intino, Alberto Albani, Giancarlo Di Iorio, Fabrizio Carinci, Giustino Parruti

Abstract read
In one paragraph

Article in BMC health services research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ennio PolilliClinical Pathology Unit, Pescara General Hospital, Pescara, Italy.
Antonella FrattariUnit of Intensive Care, Pescara General Hospital, Pescara, Italy.
Jessica Elisabetta EspositoClinical Pathology Unit, Pescara General Hospital, Pescara, Italy.
Milena D'AmatoClinical Pathology Unit, Pescara General Hospital, Pescara, Italy.
Giorgia RapacchialeDepartment of Pharmacy, Pescara General Hospital, Pescara, Italy.
Angela D'IntinoEmergency Department, Pescara General Hospital, Pescara, Italy.
Alberto AlbaniEmergency Department, Pescara General Hospital, Pescara, Italy.
Giancarlo Di IorioClinical Pathology Unit, Pescara General Hospital, Pescara, Italy.
Fabrizio CarinciDepartment of Statistical Sciences, Università di Bologna, Bologna, Italy.
Giustino ParrutiInfectious Diseases Unit, Pescara General Hospital, Pescara, Italy. giustino.parruti@ausl.pe.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe hospital management of patients diagnosed with COVID-19 can be hampered by heterogeneous characteristics at entry into the emergency department. We aimed to identify demographic, clinical and laboratory parameters associated with higher risks of hospitalisation, oxygen support, admission to intensive care and death, to build a risk score for clinical decision making at presentation to the emergency department.

methodsWe carried out a retrospective study using linked administrative data and laboratory parameters available in the initial phase of the pandemic at the emergency department of the regional reference hospital of Pescara, Abruzzo, Italy, March-June 2020. Logistic regression and Cox modelling were used to identify independent predictors for risk stratification. Validation was carried out collecting data from an extended timeframe covering other variants of concern, including Alpha (December 2020-January 2021) and Delta/Omicron (January-March 2022).

resultsSeveral clinical and laboratory parameters were significantly associated to the outcomes of interest, independently from age and gender. The strongest predictors were: for hospitalisation, monocyte distribution width ≥ 22 (4.09; 2.21-7.72) and diabetes (OR = 3.04; 1.09-9.84); for oxygen support: saturation < 95% (OR = 11.01; 3.75-41.14), lactate dehydrogenase≥237 U/L (OR = 5.93; 2.40-15.39) and lymphocytes< 1.2 × 10

conclusionsA set of parameters that are normally available at emergency departments of any hospital can be used to stratify patients with COVID-19 at risk of severe conditions. The method shall be calibrated to support timely clinical decision during the first hours of admission with different variants of concern.

Indexed as

COVID-19COVID-19 TestingDecision MakingEmergency Service, HospitalHospitalsHumansLactate DehydrogenasesOxygenPrognosisReproducibility of ResultsRetrospective StudiesLactate DehydrogenasesOxygenCOVID-19Decision makingHospitalisationIntensive carePrediction scorePrognosisSurvival

Identifiers

PMID35986291
PMCPMC9390116

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.