ArticleJournal of translational medicine2022
Combined lifestyle, mental health, and mortality in US cancer survivors: a national cohort study.
Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Combined lifestyle factors on mortality and cardiovascular disease among cancer survivors: a systematic review and meta-analysis of cohort studies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Mental health conditions among cancer survivors and individuals with and without comorbid chronic conditions: a retrospective claims analysis of patients with employee-sponsored insurance, 2012-2017.Journal of cancer survivorship : research and practice · 2026Article
- Association of pericardial fat volume with risk of incident type 2 diabetes mellitus or major adverse cardiovascular events: Evidence from UK Biobank cohort study.Nutrition & metabolism · 2026Article
- Lifestyle factors and all-cause mortality in long-term cancer survivors: a population-based prospective cohort study.European journal of epidemiology · 2026Article
- Association of healthy lifestyle, depression with all-cause or cardiovascular mortality modified by metabolic syndrome among individuals: evidence from US NHANES and UK biobank cohort studies.Nutrition & metabolism · 2026Article
- Social and Healthcare Disruptions Due to the COVID-19 Pandemic and Associations with Psychosocial Well-Being Among Cancer Survivors With and Without HIV: Findings from the MACS/WIHS Combined Cohort Study.AIDS and behavior · 2026Article
- Association between sedentary behavior, depressive symptoms, and the risk of all-cause and cause-specific mortality among U.S. cancer survivors.BMC cancer · 2025Article
- Cancer survivorship and functional health: what we need to address in an aging cancer population.Acta oncologica (Stockholm, Sweden) · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- Association between lifestyle risk factors and mortality in the Mexico City prospective study.Scientific reports · 2025Article
- Living lab modelling as a pilot study assessing the potential psychological health benefits of forest environment for cancer survivors.Obstetrics & gynecology science · 2024Article
- Association of prognostic nutritional index with mortalities in American adult cancer survivors: A cohort study based on NHANES, 1999-2018.Food science & nutrition · 2024Article
- All-Cause and Cause-Specific Mortality Among Low-Risk Differentiated Thyroid Cancer Survivors in the United States.Thyroid : official journal of the American Thyroid Association · 2024Article
- Association between workplace violence from patients and the mental health status of healthcare workers in Zhuhai China: a cross-sectional study.Frontiers in public health · 2024Article
- Association between healthy lifestyle factors and health-related quality of life among Chinese adolescents: the moderating role of gender.Health and quality of life outcomes · 2023Article
- Effects of exercise interventions on cancer-related fatigue and quality of life among cancer patients: a meta-analysis.BMC nursing · 2023Article
- Impact of lifestyle and psychological resilience on survival among the oldest-old in China: a cohort study.Frontiers in public health · 2023Article
- A comprehensive pan-cancer analysis of CDH5 in immunological response.Frontiers in immunology · 2023Article
- Interdisciplinary Integrative Oncology Group-Based Program: Evaluation of Long-Term Effects on Resilience and Use of Complementary and Alternative Medicine in Patients With Cancer.Integrative cancer therapiesObservational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdopting healthy lifestyles and staying mentally health are two cost-effective modifiable strategies that cancer survivors can implement in self-management. We aimed to evaluate the independent, mediation, interaction, and joint associations of combined lifestyle and mental health with mortality in cancer survivors.
methodsWe performed a cohort study including 3145 cancer survivors from National Health and Nutrition Examination Survey (2005-2018). A healthy lifestyle score was constructed based on post-diagnosis body mass index, physical activity, diet, smoking, and drinking. Post-diagnosis mental health was assessed by Patient Health Questionnaire (PHQ-9). Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause, cancer, and non-cancer mortality were computed using Cox proportional hazards regression models.
resultsAfter 20,900 person-years of follow-up (median, 6.3 years), cancer survivors with higher lifestyle score had decreased mortality, independent of mental health. Compared to participants with lower lifestyle score (0-1), HRs (95% CIs) for all-cause and non-cancer mortality among those with higher lifestyle score (3-5) were 0.68 (0.52-0.89) and 0.69 (0.56-0.85), respectively. 6.2-10.3% of the associations were mediated by mental health. Similar trends were observed among participants categorized by mental health, those with better mental health had lower mortality, independent of lifestyle. Participants with better mental health benefited more from adopting healthy lifestyles, and vice versa. Combinations of higher healthy lifestyle score and better mental health were associated with significant decreased mortality, the lowest mortality was seen in participants with highest healthy lifestyle score and concurrently with best mental health.
conclusionsFor the first time, in this cohort study with a nationally representative sample of US cancer survivors, we comprehensively explored the complex associations of lifestyle, mental health, and mortality. Evidence derived from this study may give much confidence to cancer survivors and healthcare providers that, changing one's lifestyle and/or staying mentally healthy after cancer diagnosis can improve survival.
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