Evidence map›Paper›PMID 35986283›Full record

ArticleJournal of nanobiotechnology2022

Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma.

Sheng Chen, Yonghong Song, Xu Yan, Liang Dong, Yunjun Xu, Shouhu Xuan, Quan Shu, Baoqiang Cao, Jinlong Hu, Hanye Xing and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Magnetic Hydrogels as a Treatment for Oncological Pathologies.Journal of functional biomaterials · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Regenerative biomaterials · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sheng Chen *Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Yonghong Song *Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Xu Yan *Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Liang DongDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei, 230026, China. dldisc@ustc.edu.cn.
Yunjun XuDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei, 230026, China.
Shouhu XuanDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei, 230026, China.
Quan ShuDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei, 230026, China.
Baoqiang CaoDepartment of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, Anhui, China.
Jinlong HuDepartment of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, Anhui, China.
Hanye XingAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Wenshu WuAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Zhengbao ZhaAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. zbzha@hfut.edu.cn.
Yang LuAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. yanglu@hfut.edu.cn.
Hefei University of Technology · CNUniversity of Science and Technology of China · CNAnhui Provincial Hospital · CN

Funding

Anhui Provincial Natural Science Foundation 2008085J06China Postdoctoral Science Foundation BH2060000173Fundamental Research Funds for the Central Universities JZ2021HGPB0059Fundamental Research Funds for the Central Universities JZ2021HGQB0279Fundamental Research Funds for the Central Universities WK2060000033Fundamental Research Funds for the Central Universities WK9110000062National Key Research and Development Program of China 2018YFE0202201National Natural Science Foundation of China 21501039National Natural Science Foundation of China 22105195National Natural Science Foundation of China 22122502National Natural Science Foundation of China 51572067National Natural Science Foundation of China 51702309National Natural Science Foundation of China 51972090University Synergy Innovation Program of Anhui Province GXXT-2020-063University Synergy Innovation Program of Anhui Province GXXT-2021-066
6 · The paper itself

Abstract

Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.

Indexed as

Carcinoma, HepatocellularHyperthermia, InducedLiver NeoplasmsAnimalsBentoniteMagnetic PhenomenaRabbitsBentoniteColloidal gelHemostasisHepatocellular carcinomaMagnetic hyperthermiaPostoperative therapy

Identifiers

PMID35986283
PMCPMC9392261
OpenAlexW4292678950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.