Evidence map›Paper›PMID 35986203›Full record

ArticleScientific reports2022

Impact of behavioral and psychological symptoms of Alzheimer's disease on caregiver outcomes.

Kanokporn Pinyopornpanish, Atiwat Soontornpun, Tinakon Wongpakaran, Nahathai Wongpakaran, Surat Tanprawate, Kanokwan Pinyopornpanish, Angkana Nadsasarn, Manee Pinyopornpanish

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  15. Neuropsychiatric symptoms in Alzheimer's disease: Bridging mechanisms, management, and emerging innovations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kanokporn PinyopornpanishDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Atiwat SoontornpunDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawarorot Rd., Sriphum, Muang, Chiang Mai, 50200, Thailand. asoontornpun@gmail.com.
Tinakon WongpakaranDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Nahathai WongpakaranDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Surat TanprawateDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawarorot Rd., Sriphum, Muang, Chiang Mai, 50200, Thailand.
Kanokwan PinyopornpanishDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawarorot Rd., Sriphum, Muang, Chiang Mai, 50200, Thailand.
Angkana NadsasarnNorthern Neuroscience Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Manee PinyopornpanishDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was to determine the prevalence of behavioral and psychological symptoms of dementia (BPSD) and its association with dementia severity and to explore the association between specific BPSD and caregiver stress, burden, and depression. A cross-sectional study involving the interviewing of the primary caregivers of patients with Alzheimer's disease (AD) was conducted. Multivariable analysis was used to analyze the associations between specific symptoms of BPSD and caregiver outcomes. A total of 102 AD patients (age 79.4 ± 7.9 years, 70.6% female) and their caregivers were included. Nearly 46% had moderate-to-severe AD. Nearly all patients (99.0%) had at least one BPSD. Apathy was among the most common symptoms (74.5%), and hallucination was the only symptom associated with severity of AD (p = 0.017). After adjustment, agitation was associated with Patient Health Questionnaire-9 (PHQ-9) and Zarit Burden Interview (ZBI-22) (p = 0.021 and 0.007, respectively); sleep disorders were associated with only PHQ-9 (p = 0.049). In conclusion, the BPSD, especially agitation and sleep disorders, can give rise to difficulties for both patients and their caregivers. The prevalence of BPSD is high (99.0%), and the symptoms can start early. Routine screening of BPSD in all AD patients is advocated.

Indexed as

Alzheimer DiseaseSleep Wake DisordersAgedAged, 80 and overBehavioral SymptomsCaregiversCross-Sectional StudiesFemaleHumansMale

Identifiers

PMID35986203
PMCPMC9391353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.