Evidence map›Paper›PMID 35986175›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2022

Insight into Isolation and Characterization of Phenolic Compounds from Hawthorn (Crataegus pinnatifida Bge.) with Antioxidant, Anti-Acetylcholinesterase, and Neuroprotective Activities.

De-Feng Liu, Ming Bai, Ning-Ning Du, Shuai Shen, Zhi-Yuan Li, Xin Zhang, Rui Guo, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neuroprotective Mechanisms ofMarine drugs · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

De-Feng Liu *Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Ming Bai *Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Ning-Ning DuKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Shuai ShenKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Zhi-Yuan LiKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Xin ZhangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Rui GuoKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Guo-Dong YaoKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Shao-Jiang SongKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China.
Xiao-Xiao HuangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang, 110016, Liaoning Province, China. xiaoxiao270@163.com.

Funding

Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University ZQN2018006Liaoning Revitalization Talents Program XLYC2007180Program for Major Scientific and Medical Technology Problems of China Medicine Education Association in 2020 2020KTS003Science and Technology Planning Project of Liaoning Province 2021JH1/10400049
6 · The paper itself

Abstract

Recent epidemiologic studies have demonstrated a link between the consumption of daily functional fruits rich in phenols and the prevention of disease for neurodegenerative disorders. Hawthorn products are derived from the functional fruit hawthorn, which is rich in phenols and has been used around the world for centuries. In order to explore the phenolic components in hawthorn, the investigation of the ethanol extract led to the separation of five new phenol compounds (1a/1b, 2-4), including one pair of enantiomers (1a/1b), along with seven disclosed analogs (5-11). Their structures were elucidated based on extensive spectroscopic analyses and electronic circular dichroism (ECD). The compounds (1-11) were tested for antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS), and ferric reducing antioxidant power (FRAP) methods. Apart from that, monomeric compounds 2, 4, and 6 exhibited more potent protective capabilities against H

Indexed as

CrataegusNeuroblastomaAcetylcholinesteraseAntioxidantsDonepezilEthanolHumansHydrogen PeroxideMolecular Docking SimulationPhenolPhenolsPlant ExtractsAcetylcholinesteraseAntioxidantsDonepezilEthanolHydrogen PeroxidePhenolPhenolsPlant ExtractsAcetylcholinesterase inhibitors activityAntioxidant activityFunctional foodHawthornNeuroprotective activity

Identifiers

PMID35986175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.