Evidence map›Paper›PMID 35985672›Full record

ArticleUnited European gastroenterology journal2022

Worldwide prevalence and burden of gastroparesis-like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

I-Hsuan Huang, Jolien Schol, Rutaba Khatun, Florencia Carbone, Karen Van den Houte, Esther Colomier, Lukas Michaja Balsiger, Hans Törnblom, Tim Vanuytsel, Elias Sundelin and 5 more

Open access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  13. Gastric AlimetryJournal of clinical medicine · 2023
    Review
  14. Gastric emptying rate and relevance for symptoms.United European gastroenterology journal · 2023
    Article
  15. Gastric sensorimotor function and its clinical measurement.Neurogastroenterology and motility · 2022
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 7 countries.

I-Hsuan HuangTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Jolien ScholTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Rutaba KhatunPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Florencia CarboneTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Karen Van den HouteTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Esther ColomierTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Lukas Michaja BalsigerTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Hans TörnblomDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-2117-9874
Tim VanuytselTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Elias SundelinSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Magnus SimrénUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Olafur S PalssonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shrikant I BangdiwalaPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Ami D SperberFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Jan TackTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.ORCID 0000-0002-3206-6704
KU Leuven · BEUniversitair Ziekenhuis Leuven · BEPopulation Health Research Institute · CAUniversity of Gothenburg · SEUniversity of North Carolina at Chapel Hill · USBen-Gurion University of the Negev · ILSteno Diabetes Centers · DKTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe global epidemiology of gastroparesis is unknown. The European UEG and European Society for Neurogastroenterology and motility consensus defines Gastroparesis as a condition characterized by delayed gastric emptying in the absence of mechanical obstruction, with a symptom pattern of nausea and/or vomiting and overlapping postprandial distress syndrome (PDS). Real-world evidence of this gastroparesis-like symptom pattern is a crucial step in understanding the epidemiology of gastroparesis.

methodsIn the Rome Foundation Global Epidemiology Study, 54,127 respondents from 26 countries completed the Rome IV Diagnostic Questionnaire and variables associated with disorders of gut-brain interaction via Internet. We selected subjects with gastroparesis-like symptoms (GPLS) (nausea and/or vomiting ≥1 day/week and simultaneous PDS). Patients reporting organic gastrointestinal disease, or fulfilling criteria for self-induced vomiting, cyclic vomiting or cannabinoid hyperemesis syndrome were excluded. We determined prevalence, associated comorbidities, quality of life (QoL) (PROMIS Global-10), symptoms of anxiety and depression (PHQ-4), somatic symptoms (PHQ-12), and healthcare utilization.

resultsThe global prevalence of GPLS was 0.9% overall and 1.3% among diabetic individuals. Subjects with GPLS showed frequent overlapping of epigastric pain syndrome and irritable bowel syndrome. Subjects with GPLS had significantly lower body mass index, QoL, more non-gastrointestinal somatic complaints, symptoms of anxiety and depression, higher medication usage and doctor visits in the overall and diabetic population, compared to subjects without these symptoms.

conclusionsGPLS are common worldwide and more common in diabetic patients. The symptom complex is associated with multiple aspects of illness and an increased healthcare consumption.

Indexed as

CannabinoidsDyspepsiaGastroenterologyGastroparesisHumansNauseaPrevalenceQuality of LifeVomitingCannabinoidsgastroparesisgastroparesis-like symptomsprevalence

Identifiers

PMID35985672
PMCPMC9557951
OpenAlexW4294007277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.