Evidence map›Paper›PMID 35985643›Full record

ArticleBiochemistry2022

The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against

Isabelle R Taylor, Philip D Jeffrey, Dina A Moustafa, Joanna B Goldberg, Bonnie L Bassler

Open access · hybridAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. New inhibitors of themSphere · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. PqsE adapts the activity of theJournal of bacteriology · 2025
    Article
  7. Review
  8. Quorum Sensing and its Inhibition inCurrent drug targets · 2025
    Review
  9. Busulfan inhibitsFrontiers in cellular and infection microbiology · 2025
    Article
  10. Identification of a dCache-type chemoreceptor inFrontiers in microbiology · 2024
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Isabelle R TaylorDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-1053-5677
Philip D JeffreyDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Dina A MoustafaSchool of Medicine, Children's Healthcare of Atlanta, Inc., Department of Pediatrics, and Center for Cystic Fibrosis and Airway Diseases Research, Emory University, Atlanta, Georgia 30322, United States.
Joanna B GoldbergSchool of Medicine, Children's Healthcare of Atlanta, Inc., Department of Pediatrics, and Center for Cystic Fibrosis and Airway Diseases Research, Emory University, Atlanta, Georgia 30322, United States.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-0043-746X
Emory University · USPrinceton University · USHoward Hughes Medical Institute · US

Funding

Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Targeting the bacterialthioesterase, PqsE, for the treatment of Pseudomonas aeruginosa infectionsF32GM134583 · NIGMS · PRINCETON UNIVERSITY · PI TAYLOR, ISABELLE · 2019 to 2021
$192k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM134583NIGMS NIH HHS R37 GM065859
6 · The paper itself

Abstract

The opportunistic pathogen

Indexed as

Pseudomonas aeruginosaPseudomonas InfectionsAnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsCatalytic DomainHumansMiceQuorum SensingAnti-Bacterial AgentsBacterial Proteins

Identifiers

PMID35985643
PMCPMC9454246
OpenAlexW4294015752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.