Evidence map›Paper›PMID 35985535›Full record

ArticleThe Journal of pediatrics2022

The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.

Sheela N Magge, Risa M Wolf, Laura Pyle, Elizabeth A Brown, Valeria C Benavides, Monica E Bianco, Lily C Chao, Anna Cymbaluk, Pinar Gumus Balikcioglu, Kelsee Halpin and 18 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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  8. Trends of Diabetes in Youth (TrenDY) During COVID-19 Across the United States.The Journal of clinical endocrinology and metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 1 country.

Sheela N MaggeDivision of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.
Risa M WolfDivision of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.
Laura PyleDepartment of Pediatrics, University of Colorado Anschutz Medical Campus/Children's Hospital Colorado, Aurora, CO.
Elizabeth A BrownDivision of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.
Valeria C BenavidesDepartment of Pediatrics, Division of Endocrinology, University of Illinois, College of Medicine of Peoria/Children's Hospital of Illinois, Peoria, IL.
Monica E BiancoDepartment of Pediatrics, Division of Pediatric Endocrinology, Northwestern University/Ann and Robert H Lurie Children's Hospital, Chicago, IL.
Lily C ChaoCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA.
Anna CymbalukDepartment of Pediatric Diabetes and Endocrinology, Texas Children's Hospital/Baylor College of Medicine, Houston, TX.
Pinar Gumus BalikciogluDivision of Pediatric Endocrinology and Diabetes and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC.
Kelsee HalpinDivision of Endocrinology and Diabetes, University of Missouri-Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, MO.
Daniel S HsiaOur Lady of the Lake Children's Hospital/Pennington Biomedical Research Center, Baton Rouge, LA.
Lina Huerta-SaenzDepartment of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Penn State Health Children's Hospital/Penn State College of Medicine, Hershey, PA.
Jane J KimDepartment of Pediatrics, Division of Pediatric Endocrinology, University of California San Diego/Rady Children's Hospital San Diego, San Diego, CA.
Seema KumarDepartment of Pediatrics, Division of Pediatric Endocrinology, Mayo Clinic, Rochester, MN.
Lorraine E Levitt KatzDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA.
Brynn E MarksDivision of Endocrinology and Diabetes, Children's National Hospital, Washington DC.
Anna NeymanDepartment of Pediatrics, Indiana University School of Medicine/Riley Hospital for Children, Indianapolis, IN.
Katie L O'SullivanSection of Adult & Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center, Chicago, IL.
Sabitha Sasidharan PillaiDivision of Pediatric Endocrinology, Warren Alpert Medical School of Brown University/Hasbro Children's Hospital, Providence, RI.
Amy S ShahDivision of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center & The University of Cincinnati, Cincinnati, OH.
Ashley H ShoemakerDepartment of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, TN.
Juwairriyyah A W SiddiquiDepartment of Pediatrics, Columbia University Irving Medical Center, Harlem Hospital, New York, NY.
Shylaja SrinivasanDepartment of Pediatrics, Division of Endocrinology, University of California, San Francisco, San Francisco, CA.
Inas H ThomasDepartment of Pediatrics, Pediatric Endocrinology, University of Michigan, Ann Arbor, MI.
Jeanie B TryggestadDepartment of Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Maha F YousifDepartment of Pediatrics, Pediatric Endocrinology, University of Texas Southwestern, Dallas, TX.
Megan M KelseyDepartment of Pediatrics, University of Colorado Anschutz Medical Campus/Children's Hospital Colorado, Aurora, CO. Electronic address: megan.kelsey@childrenscolorado.org.
COVID-19 and Type 2 Diabetes Consortium
Brown University · USChildren's Hospital Colorado · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's National · USColumbia University · USDuke Medical Center · USIllinois College · USIndiana University – Purdue University Indianapolis · USJohns Hopkins Hospital · USJohns Hopkins Medicine · USJohns Hopkins University · USLurie Children's Hospital · USMayo Clinic in Arizona · USOur Lady of the Lake Children's Hospital · USPenn State Milton S. Hershey Medical Center · USTexas Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Diego · USUniversity of California, San Francisco · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Training Program in Pediatric EndocrinologyT32DK007161 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian J Feldman, STEPHEN E GITELMAN · 1986 to 2026
$6.2M
Genetics of Early Childhood Obesity and its Clinical ImplicationsK23DK110539 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI THAKER, VIDHU V. · 2016 to 2021
$996k
Developing a patient-centered psychoeducational tool to realize the potential of diabetes technologiesK23DK129827 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI MARKS, BRYNN E · 2022 to 2025
$842k
NIDDK NIH HHS K23 DK110539NIDDK NIH HHS K23 DK129827NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK116073NIDDK NIH HHS T32 DK007161
6 · The paper itself

Abstract

objectivesTo evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of the previous 2 years. STUDY

designMulticenter (n = 24 centers), hospital-based, retrospective chart review. Youth aged ≤21 years with newly diagnosed type 2 diabetes between March 2018 and February 2021, body mass index ≥85th percentile, and negative pancreatic autoantibodies were included. Demographic and clinical data, including case numbers and frequency of metabolic decompensation, were compared between groups.

resultsA total of 3113 youth (mean [SD] 14.4 [2.4] years, 50.5% female, 40.4% Hispanic, 32.7% Black, 14.5% non-Hispanic White) were assessed. New cases of type 2 diabetes increased by 77.2% in the year during the pandemic (n = 1463) compared with the mean of the previous 2 years, 2019 (n = 886) and 2018 (n = 765). The likelihood of presenting with metabolic decompensation and severe diabetic ketoacidosis also increased significantly during the pandemic.

conclusionsThe burden of newly diagnosed youth-onset type 2 diabetes increased significantly during the coronavirus disease 2019 pandemic, resulting in enormous strain on pediatric diabetes health care providers, patients, and families. Whether the increase was caused by coronavirus disease 2019 infection, or just associated with environmental changes and stressors during the pandemic is unclear. Further studies are needed to determine whether this rise is limited to the US and whether it will persist over time.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisAdolescentChildFemaleHumansMalePandemicsRetrospective Studies

Identifiers

PMID35985535
PMCPMC9383958
OpenAlexW4292684653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.