ArticleBrain stimulation
Percepts evoked by multi-electrode stimulation of human visual cortex.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Seeing anew: Mechanisms, outcomes, and challenges in adapting to restored sight via visual prostheses.Progress in retinal and eye research · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- logLIRA: a method for reliable suppression of electrical stimulation artifacts enabling short-latency neural response recovery.Journal of neural engineering · 2026Article
- The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex.Brain communications · 2026Article
- Selective activation of mesoscale functional circuits via multichannel infrared stimulation of cortical columns in ultra-high-field 7T MRI.Cell reports methods · 2025Article
- Longitudinal stability of individual brain plasticity patterns in blindness.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation.Nature communications · 2024Article
- A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts.Scientific reports · 2024Article
- Evoking artificial speech perception through invasive brain stimulation for brain-computer interfaces: current challenges and future perspectives.Frontiers in neuroscience · 2024Review
- Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024Review
- Longitudinal stability of individual brain plasticity patterns in blindness.bioRxiv : the preprint server for biology · 2023Article
- Attitudes of potential recipients toward emerging visual prosthesis technologies.Scientific reports · 2023Article
- Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys.Journal of neural engineering · 2023Article
- Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges.Frontiers in cellular neuroscience · 2022Article
- Review of brain-computer interface technology in ophthalmology: Current status, challenges and future directions.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDirect electrical stimulation of early visual cortex evokes the perception of small spots of light known as phosphenes. Previous studies have examined the location, size, and brightness of phosphenes evoked by stimulation of single electrodes. While it has been envisioned that concurrent stimulation of many electrodes could be used as the basis for a visual cortical prosthesis, the percepts resulting from multi-electrode stimulation have not been fully characterized.
objectiveTo understand the rules governing perception of phosphenes evoked by multi-electrode stimulation of visual cortex.
methodsMulti-electrode stimulation was conducted in human epilepsy patients. We examined the number and spatial arrangement of phosphenes evoked by stimulation of individual multi-electrode groups (n = 8), and the ability of subjects to discriminate between the pattern of phosphenes generated by stimulation of different multi-electrode groups (n = 7).
resultsSimultaneous stimulation of pairs of electrodes separated by greater than 4 mm tended to produce perception of two distinct phosphenes. Simultaneous stimulation of three electrodes gave rise to a consistent spatial pattern of phosphenes, but with significant variation in the absolute location, size, and orientation of that pattern perceived on each trial. Although multi-electrode stimulation did not produce perception of recognizable forms, subjects could use the pattern of phosphenes evoked by stimulation to perform simple discriminations.
conclusionsThe number of phosphenes produced by multi-electrode stimulation can be predicted using a model for spread of activity in early visual cortex, but there are additional subtle effects that must be accounted for.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.