Evidence map›Paper›PMID 35985331›Full record

ArticleStem cell reports2022

Neuroblast migration along cellular substrates in the developing porcine brain.

Demisha D L Porter, Sara N Henry, Sadia Ahmed, Amy L Rizzo, Rita Makhlouf, Collin Gregg, Paul D Morton

Abstract read
In one paragraph

Article in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demisha D L PorterVirginia Tech Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Sara N HenryDepartment of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Sadia AhmedDepartment of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Amy L RizzoOffice of the University Veterinarian & Animal Resources, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Rita MakhloufDepartment of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Collin GreggVirginia Tech Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Paul D MortonDepartment of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. Electronic address: pmorton@vt.edu.

Funding

Neural migratory deficits in congenital heart diseaseR15NS108183 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MORTON, PAUL DAVID · 2019 to 2020
$613k
NINDS NIH HHS R15 NS108183
6 · The paper itself

Abstract

In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models. We reasoned that migratory streams of neuroblasts utilize cellular substrates, such as blood vessels, to guide their trek from the subventricular zone to distant cortical targets. Here, we evaluate the association between young interneuronal migratory streams and their preferred cellular substrates in gyrencephalic piglets during the developmental equivalent of human birth, infancy, and toddlerhood.

Indexed as

Neural Stem CellsAnimalsBrainCell MovementHumansLateral VentriclesMiceNeurogenesisOlfactory BulbSwinegliophilicmigrationneuroblastneurodevelopmentneurogenesisporcinepostnatal developmentsubventricular zoneswinevasophilic

Identifiers

PMID35985331
PMCPMC9481921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.