Evidence map›Paper›PMID 35985075›Full record

ReviewCurrent opinion in neurobiology2022

Understanding neuroinflammation through central nervous system infections.

Hannah J Johnson, Anita A Koshy

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hannah J JohnsonNeuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
Anita A KoshyNeuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA; Department of Neurology, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA. Electronic address: akoshy@arizona.edu.
University of Arizona · US

Funding

Neuronal Latency and ToxoplasmaR01AI157247 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOPHER A HUNTER, Anita Koshy · 2020 to 2026
$4.7M
Defining neuron-Toxoplasma gondii interactions that mediate CNS toxoplasmosisR01NS095994 · NINDS · UNIVERSITY OF ARIZONA · PI KOSHY, ANITA · 2016 to 2020
$2.0M
Translational research in Alzheimer’s Disease and Related Dementias (TRADD)T32AG061897 · NIA · UNIVERSITY OF ARIZONA · PI BRINTON, ROBERTA EILEEN · 2018 to 2022
$1.3M
NIAID NIH HHS R01 AI157247NIA NIH HHS T32 AG061897NINDS NIH HHS R01 NS095994
6 · The paper itself

Abstract

Neuroinflammation is now recognized to compound many central nervous system (CNS) pathologies, from stroke to dementia. As immune responses evolved to handle infections, studying CNS infections can offer unique insights into the CNS immune response and address questions such as: What defenses and strategies do CNS parenchymal cells deploy in response to a dangerous pathogen? How do CNS cells interact with each other and infiltrating immune cells to control microbes? What pathways are beneficial for the host or for the pathogen? Here, we review recent studies that use CNS-tropic infections in combination with cutting-edge techniques to delve into the complex relationships between microbes, immune cells, and cells of the CNS.

Indexed as

Central Nervous System InfectionsNeuroinflammatory DiseasesCentral Nervous SystemHumans

Identifiers

PMID35985075
PMCPMC10147316
OpenAlexW4292013672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.