ArticleScience advances2022
Natural locus coeruleus dynamics during feeding.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed.
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors.Journal of neuroendocrinology · 2026Article
- Nutrient-dependent hippocampus dopamine signaling enhances meal-related episodic memory and reduces food intake.bioRxiv : the preprint server for biology · 2026Article
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Visual attention is linked to temporally structured noradrenaline release in the medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cellular signatures of melanocortin pathway genes across the locus coeruleus.Acta neuropathologica communications · 2026Article
- Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Next-generation multicolor indicators for in vivo imaging of norepinephrine.Nature methods · 2026Article
- Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states.Neuron · 2026Article
- Mapping the Central Autonomic Network Nodes Integrating Cardiovascular and Metabolic Control.Cellular and molecular neurobiology · 2026Article
- Paraventricular nucleus-locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice.Cell death & disease · 2025Article
- Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model.bioRxiv : the preprint server for biology · 2025Article
- Stress reactivity is modulated by cannabinoid type-1 receptors in norepinephrine and epinephrine neurons in a context-dependent manner.Neuroscience · 2025Article
- Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety.Science advances · 2025Article
- A hypothalamus-brainstem circuit governs the prioritization of safety over essential needs.Nature neuroscience · 2025Article
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- Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.Experimental & molecular medicine · 2025Review
- A superior colliculus-originating circuit prevents cocaine reinstatement via VR-based eye movement desensitization treatment.National science review · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was suppressed during food consumption, and the magnitude of this neural response was attenuated as mice consumed more pellets throughout the session, suggesting that LC responses to food are modulated by satiety state. Visual-evoked LC-NE activity was also attenuated in sated mice, suggesting that satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by brief or longer durations of LC-NE activation. Last, we found that activation of the LC to the lateral hypothalamus pathway suppresses feeding and enhances avoidance and anxiety-like responding. Our findings suggest that LC-NE neurons modulate feeding by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g., satiety).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.